The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $385,161 project grant on Sep 5, 2024 under the Oral Diseases and Disorders Research (CFDA 93.121) program to the Board of Regents of the University of Nebraska's University of Nebraska Medical Center (UNMC) Division. This grant aims to investigate the role of p21 positive senescent cells in obesity, aging, and trauma-induced temporomandibular joint (TMJ) degeneration, a painful and debilitating joint disease...
This $222,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at The Children's Hospital of Philadelphia (CHOP) to investigate the pathogenic mechanisms of temporomandibular joint (TMJ) osteophyte formation. The key objectives are to test whether conditional ablation of the gene EXT1, which is involved in heparan sulfate synthesis, causes osteophyte formation...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $738,929 to The Trustees of Columbia University in the City of New York to develop and validate a patient-specific TMJ-on-a-chip (TMJOC) model. The TMJOC will be used to investigate multi-tissue crosstalk regulating temporomandibular joint (TMJ) disc injury and healing under inflammation and pathophysiological...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research on the role of hyaluronan (HA) in temporomandibular joint (TMJ) health and pathology. The $507,006 award, with a project period from August 1, 2025 to July 31, 2027, will be administered by The Children's Hospital of Philadelphia (CHOP). The key objectives of this research project are to investigate the...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $1,013,625 to the University of Pittsburgh to investigate the use of a porcine small intestine submucosa (SIS) scaffold for temporomandibular joint (TMJ) disc regeneration. The goal is to develop a safe and effective treatment for TMJ disc replacement, addressing the lack of FDA-approved options that leads to joint...
The federal Cooperative Agreement award UH3DE032204 was granted by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The $1,660,925.63 award supports a project at Thomas Jefferson University's Sidney Kimmel Medical College to utilize single-cell RNA sequencing to identify and classify cell populations and gene expression in temporomandibular joint (TMJ) synovial fluid from healthy and symptomatic TMJ...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,325,889 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Southern California on September 19, 2024. This grant, titled "Regulating Skeletal Connectivity in Craniofacial Development and Disease," will support a comprehensive and forward-thinking research program led by Dr. Amy Merrill that investigates the craniofacial skeleton as a multi-tissue...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, provides $688,679 to the University of Southern California (USC) to conduct innovative research mapping the transcriptomes and lineage relationships of cell types in the developing vertebrate face. The goal is to develop new technology capable of uniquely labeling and permanently tracing the lineages of all cells...
This federal Project Grant award, valued at $161,762.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the role of the NG2/CSPG4 protein in the healing of endochondral fractures in the mandible. The research aims to define the specific molecular pathways by which NG2/CSPG4 regulates the differentiation of osteochondral progenitor cells during fracture repair, with the...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $143,285 project grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Southern California (USC). The project aims to identify the cellular origins of cartilage regeneration in the zebrafish jaw joint, which could inform future treatments for temporomandibular joint osteoarthritis (TMJ OA) in humans. The grant will fund research to optimize a transgenic cartilage ablation model in zebrafish and investigate potential progenitor cell sources that contribute to joint cartilage regeneration, including the perichondrium, deeper chondrocytes, and residual superficial chondrocytes. Single-cell multi-omic analysis will also be conducted to uncover unbiased progenitor populations activated during joint repair. This 4-year project, starting on January 1, 2025, seeks to elucidate the cellular mechanisms underlying the zebrafish's remarkable ability to regenerate specialized joint cartilage, which could inform future strategies to stimulate cartilage regeneration in humans affected by TMJ OA and other joint disorders.