Project Grant R56CA286906

Award Date 9/12/24
Completion Date 8/31/25
Dollars Obligated $165K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
미국 뉴욕
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This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) supports research on the mechanisms underlying brain metastasis in patients with EGFR-mutant lung cancer. Specifically, the $164,500 award, which runs from September 2024 to August 2025, aims to:

  1. Investigate how the protein S100A9 is epigenetically regulated and drives the expression of pro-metastatic genes in the brain, using a combination of epigenome profiling and editing technologies.

  2. Determine how S100A9 functions as a transcriptional activator to promote brain metastasis through the activation of the CES1 gene, which alters lipid metabolism. This will involve the use of immunocompetent and patient-derived brain metastasis models.

The research is being conducted by the Acharyya and Lu labs at Columbia University's Health Sciences Division, a prominent academic research institution with significant expertise in biomedical research and federal grant support.

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