This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) supports research on the mechanisms underlying brain metastasis in patients with EGFR-mutant lung cancer. Specifically, the $164,500 award, which runs from September 2024 to August 2025, aims to: Investigate how the protein S100A9 is epigenetically regulated and drives the expression of pro-metastatic genes in the brain, using a combination of epigenome profiling and editing technologies. Determine how S100A9 functions as a transcriptional activator to promote brain metastasis through the activation of the CES1 gene, which alters lipid metabolism. This will involve the use of immunocompetent and patient-derived brain metastasis models. The research is being conducted by the Acharyya and Lu labs at Columbia University's Health Sciences Division, a prominent academic research institution with significant expertise in biomedical research and federal grant support.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $164.5k | 9/13/24 |