The Trustees of Columbia University in the City of New York is the recipient of a $1,480,500 Project Grant award from the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The grant, awarded on September 1, 2024, will support the development of a comprehensive, spatiotemporally-resolved roadmap of small cell lung cancer (SCLC) metastasis. The project aims to elucidate the cell intrinsic and extrinsic mechanisms underlying SCLC metastasis, which is a leading cause of cancer deaths globally. Through innovative lineage tracing, spatial mapping, and signal recording techniques, the researchers will map the evolutionary dynamics, spatial context, and molecular features of SCLC metastasis progression. The project's technical advances and biological discoveries are expected to transform the understanding of cancer metastasis and inform the development of novel, stage/gene/environment-specific therapeutic strategies to limit SCLC metastatic spread.