This Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) provides $730,398 to the Sloan-Kettering Institute for Cancer Research to investigate the relationship between leptomeningeal cancer cell growth and inflammatory signaling in the leptomeninges, the membranes surrounding the brain and spinal cord.
The research aims to mechanistically dissect the CXCL1-CXCR2 signaling axis within the leptomeningeal space, identifying cancer cell signals that provoke leptomeningeal CXCL1 generation and characterizing cancer cell responses to leptomeningeal-generated cytokines. This comprehensive approach leverages the institution's collection of human samples, molecular interrogation capabilities, and innovative mouse modeling techniques to capture the molecular interplay between cancer cells and the leptomeningeal microenvironment. The research seeks to identify clinically-relevant targets against leptomeningeal metastasis, a destructive central nervous system malignancy with limited treatment options.
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