This federal Project Grant award, numbered R21AI183320, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The total funding amount is $256,808.00 for the project period from March 21, 2025 to February 28, 2027.
The goal of this research project is to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The key focus areas include: 1)...
This Project Grant award of $1,517,519 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program) supports research to identify the upstream drivers of type I interferon production in systemic lupus erythematosus (SLE). The project, titled "Upstream Drivers of Type I Interferons in Lupus", focuses on understanding the molecular mechanisms by which innate immune cells, such as neutrophils and monocytes, and skin cells...
This $2,902,477 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a study exploring remission and relapse in patients with systemic lupus erythematosus (SLE). The research aims to analyze immune cell profiles and brain function in SLE patients in long-term clinical remission to understand patient heterogeneity, identify predictors of sustained remission or flare, and reveal novel states of immune...
This $788,508 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) supports research into the regulatory mechanisms linking Langerhans cells and lymphatic function in systemic lupus erythematosus (SLE). The award recipient, The Hospital for Special Surgery Fund, Inc. (doing business as HSS Foundation), will conduct this 5-year research project to investigate how...
The University of Massachusetts Medical School was awarded a $494,929 Project Grant from the National Institute of Allergy and Infectious Diseases to study the role of Toll-like receptors, type II interferon and type III interferon in a murine model of autoinflammation. The grant will support research exploring the effector mechanisms responsible for inducing and regulating cutaneous lupus using genetically modified mice with discriminating mutations. Specifically, the researchers will use...
This $375,100 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will support a research study focused on understanding the role of cyclic GMP-AMP synthase (cGAS) activation and nucleic-acid-dependent phase separation in regulating immune responses associated with systemic lupus erythematosus (SLE).
The study, led by researchers at The Johns...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $895,140 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Progentec Diagnostics Inc., a minority-owned small business located in Oklahoma City, OK. The purpose of this late-stage research project is to validate two innovative laboratory tests, the Lupus Flare Risk Index (L-FRI) and the Lupus Disease Activity Index (L-DAI), which are designed to detect immune dysregulation...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $793,093 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the Oklahoma Medical Research Foundation (OMRF) to define the regulatory landscape of systemic lupus erythematosus (SLE) with cardiovascular disease (CVD) comorbidity.
The research project aims to systematically study thousands of SLE-associated genetic variants to identify causal regulatory elements, target genes, and cell...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the CFDA Program "Arthritis, Musculoskeletal and Skin Diseases Research", provides $300,000 in funding to the Beckman Research Institute of the City of Hope to conduct research on eradicating pathogenic plasma cells and their precursors in Systemic Lupus Erythematosus (SLE).
The research aims to determine the effect of knocking down the long isoform of the prolactin...
The National Institute of Allergy and Infectious Diseases awarded a $224,070 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Regents of the University of Minnesota from November 2024 to October 2026. The grant supports research to investigate how immune cells and stromal cells, such as fibroblasts and endothelial cells, interact and communicate to perpetuate autoimmune-driven inflammation and fibrosis in cardiac valves. The research aims to define...