This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $657,673 to the Regents of the University of Minnesota to conduct research on non-deletional CD8+ T cell tolerance. The research aims to define the gene regulation that inhibits self-reactive CD8+ T cells and classify different types of self-reactive CD8+ T cell clones, in order to understand which tolerance...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) provides $247,236 to the Regents of the University of Minnesota to investigate the expansion and function of long-lived effector CD8 T cells in the mature memory compartment. The research aims to determine the proinflammatory cytokines that support the formation and persistence of this T cell population, as well as how...
This Federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $162,486 to the Regents of the University of Minnesota to investigate the local and systemic coordination of antiviral immunity by tissue-resident memory CD8 T cells in the skin. The project aims to determine whether CD8 tissue-resident memory T cells (TRM) can orchestrate immune cell responses in the skin and influence distal immunity....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $195,894.00 to The Washington University to study the mechanisms contributing to T cell dysregulation in STAT3 gain-of-function (GOF) syndrome. The primary scientific goal is to investigate critical interactions between T and B cells, as well as the development, polarization, and function of these cells, in order to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $2,999,774 to the Regents of the University of Minnesota to conduct research focused on understanding how maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal-fetal interface. The key objectives are to investigate the regulation of CD8 T cell tolerance and host immune defense...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $806,693.00 to New York University (NYU) from June 12, 2025 to May 31, 2030. The grant supports research to elucidate the mechanisms governing lymphangiogenesis (growth of lymphatic vessels) in acute and homeostatic inflammation, and to determine the functional consequences of lymphatic encapsulation of B...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $459,250 to Cedars-Sinai Medical Center to conduct research on the mechanisms of fibroblast-like synoviocyte (FLS) transmigration through endothelial cell (EC) layers in rheumatoid arthritis (RA). The key objectives are to validate a pathway connecting FLS transmigration with EC-mediated inflammation using RA synovial...
This $793,093 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to define the regulatory landscape of systemic lupus erythematosus (SLE) and its cardiovascular disease (CVD) comorbidity. The grantee, Oklahoma Medical Research Foundation, will conduct systematic, high-throughput studies in macrophages derived from induced pluripotent stem cells to identify genetic variants that disrupt regulatory...
This Project Grant award of $2,841,668.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research focused on understanding how the bacterial enzyme SagB in Staphylococcus aureus (S. aureus) modulates the host immune response and promotes infection. The key goals are to determine how SagB-modified peptidoglycan is recognized by immune cells, investigate the mechanism of SagB-dependent IL-1β...
This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to examine the role of B cell-dependent regulatory T cells in maintaining B cell tolerance and preventing autoimmunity. The $807,799 award to the University of Chicago aims to identify B cell-dependent regulatory T cell clones, define their developmental requirements and functions, and determine the...