This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000 microglial cells from autopsy samples. Additionally, the researchers will use human induced pluripotent stem cell-derived microglia to functionally test the hypothesis that endolysosomal network dysfunction and DNA damage response contribute to neuronal toxicity in Alzheimer's disease. The award period is from September 15, 2023 to August 31, 2024.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $871.4k | 9/13/23 |