This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $188,892 to investigate the role of microglial subpopulations in resilience to Alzheimer's disease. The key objectives are to: 1) Identify microglial subpopulations in individuals resilient to Alzheimer's pathology, both in humans and in a mouse model, using single-nucleus RNA sequencing; and 2) Develop techniques to modify gene expression in specific microglial subpopulations, and test these in in vitro and in vivo models. The research aims to enhance the biological understanding of resilience to Alzheimer's disease and develop the capacity to manipulate microglial subpopulations, with the goal of identifying mediators of the relationship between Alzheimer's pathology and cognitive impairment that could be targeted therapeutically. The project period runs from January 1, 2025 to December 31, 2027.
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