Project Grant R44NS143568
- This Project Grant award of $455,371 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding the development and validation of a novel microchip-based platform for the discovery and characterization of migraine therapies. The key products and services to be delivered under this award include: Quantifying comprehensive neurovascular and behavioral responses to established migraine triggers and...
- This Project Grant award of $472,592 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to evaluate RGIA5474, a peripherally-restricted and highly selective a9a10 nicotinic acetylcholine receptor (nAChR) antagonist, as a potential novel treatment for migraine. The researchers from the New York Institute of Technology (NYIT) hypothesize that blocking...
- The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $415,249 Project Grant to the Regents of the University of Michigan. The grant aims to establish predictive measures of migraine onset through continuous monitoring of autonomic activity using wrist-worn devices in individuals with episodic migraine. The project will identify predictive markers of migraine attack...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,375.00 to support research on the role of the GPR37L1 receptor in chronic migraine. The funding will enable a research team at Florida Atlantic University, with a sub-award to the University of Florida, to conduct a comprehensive investigation into the involvement of GPR37L1 signaling in the neuropathology of...
- This Project Grant award of $444,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The researchers at the University of Virginia will use mouse models to measure pain responses and neuronal activity during experimentally-induced migraine...
- This federal Project Grant award from the National Center for Complementary and Integrative Health (CFDA 93.213 - Research and Training in Complementary and Integrative Health) provides $753,142 to conduct a feasibility trial of a home-based immersive neurofeedback self-regulation training (INSERT) intervention for the preventive treatment of pediatric migraine. The grant recipient, Children's Mercy Hospital, will evaluate enrollment, retention, and outcome assessment procedures for a future...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a feasibility trial of a remotely-delivered mindfulness-based intervention for adolescents with migraine. The $198,129 award to the University of Colorado-Denver will fund a pilot study to evaluate the feasibility, acceptability, and preliminary efficacy of a virtual...
- This federal Project Grant award, totaling $475,475.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The objective of this 2-year research project, running from July 1, 2025 to June 30, 2027, is to investigate the relationship between circadian-driven complement system activation, ATP release from red blood cells, and the onset of morning migraine...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $299,982 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Unandup, LLC, a technology development firm in St. Louis, Missouri. The grant funding supports the development of the Commercialization Readiness Pilot for the FAST (Flow Acceleration for Stroke Thrombolysis) System, an innovative medical device platform designed to safely accelerate the...
- This $498,995 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports the development of a highly parallelized interferometric near-infrared spectroscopy (INIRS) platform for the real-time, non-invasive measurement of cerebral blood flow. The research aims to address the limitations of current stroke diagnosis and monitoring techniques...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of the "MI-HELPER" device, a novel thermodynamic neuromodulation approach for migraine relief. The $983,042 award to Cooltech, LLC aims to demonstrate the device's capacity for fast, convenient, and drug-free symptom reduction for migraine through the targeted cooling of the sphenopalatine ganglion nerve bundle. The project will run from September 2025 through August 2027, building on previous in-clinic and randomized controlled studies that have shown promise for this non-invasive, air-based migraine treatment approach.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $983.0k | 9/17/25 |