Project Grant R21NS145442
- This Project Grant award of $455,371 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding the development and validation of a novel microchip-based platform for the discovery and characterization of migraine therapies. The key products and services to be delivered under this award include: Quantifying comprehensive neurovascular and behavioral responses to established migraine triggers and...
- This Project Grant award of $444,125.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to investigate the role of progesterone receptors in regulating the transition from episodic to chronic migraine. The researchers at the University of Virginia will use mouse models to measure pain responses and neuronal activity during experimentally-induced migraine...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,375.00 to support research on the role of the GPR37L1 receptor in chronic migraine. The funding will enable a research team at Florida Atlantic University, with a sub-award to the University of Florida, to conduct a comprehensive investigation into the involvement of GPR37L1 signaling in the neuropathology of...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports the development of the "MI-HELPER" device, a novel thermodynamic neuromodulation approach for migraine relief. The $983,042 award to Cooltech, LLC aims to demonstrate the device's capacity for fast, convenient, and drug-free symptom reduction for migraine through the targeted...
- This federal Project Grant award, totaling $475,475.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The objective of this 2-year research project, running from July 1, 2025 to June 30, 2027, is to investigate the relationship between circadian-driven complement system activation, ATP release from red blood cells, and the onset of morning migraine...
- This Project Grant award of $472,592 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to evaluate RGIA5474, a peripherally-restricted and highly selective a9a10 nicotinic acetylcholine receptor (nAChR) antagonist, as a potential novel treatment for migraine. The researchers from the New York Institute of Technology (NYIT) hypothesize that blocking...
- This Project Grant award of $317,000 from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), supports research to determine how chronic migraine accelerates the development of Alzheimer's disease (AD) pathology and cognitive decline in a preclinical mouse model of AD. The key objectives are to: 1) Assess the impact of chronic migraine on multiple domains of cognition in an AD mouse model using clinical tests, and 2) Analyze gene and protein...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a feasibility trial of a remotely-delivered mindfulness-based intervention for adolescents with migraine. The $198,129 award to the University of Colorado-Denver will fund a pilot study to evaluate the feasibility, acceptability, and preliminary efficacy of a virtual...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $147,486 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Massachusetts Institute of Technology (MIT) from July 1, 2025 to June 30, 2027. The grant funds the development of a novel Magnetic Resonance Imaging (MRI) method to concurrently measure brain tissue displacement, blood dynamics, and cerebrospinal fluid (CSF) flow in humans. This research...
- The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded a $3,045,502 Project Grant to the Regents of the University of Michigan on August 18, 2022 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The grant funds the development of optical neural motes to enable high-density neural recording through intact dura in nonhuman primates. Specifically, the University of Michigan will design...
The National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), awarded a $415,249 Project Grant to the Regents of the University of Michigan. The grant aims to establish predictive measures of migraine onset through continuous monitoring of autonomic activity using wrist-worn devices in individuals with episodic migraine. The project will identify predictive markers of migraine attack and differentiate objective versus subjective evaluative measures to enhance prediction accuracy. Using machine learning, the university will develop algorithms to forecast migraine onset, with the goal of enabling preemptive treatment and improving patient outcomes. The award period is from August 7, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $415.2k | 8/7/25 |