This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,375.00 in funding to Florida Atlantic University (FAU) to conduct research on the role of the GPR37L1 receptor in chronic migraine-like conditions.
The key objectives of the research project are to: 1) assess GPR37L1 expression and localization in animal models of chronic migraine, 2) examine the impact of GPR37L1 deletion on astrocyte regulation of neuronal activity, and 3) evaluate the effects of GPR37L1 genetic deletion on chronic migraine symptoms in male and female mice. This interdisciplinary effort combines genetic, biochemical, electrophysiological, and behavioral approaches to improve understanding of how GPR37L1 signaling may play a protective role in migraine pathology. The project is expected to generate insights that could have broad implications for the treatment of neurological disorders.
Generated 1/28/25, 9:14 AM