Project Grant R44NS093756

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,499,886 to Astrocyte Pharmaceuticals Inc. to conduct preclinical efficacy and safety evaluation of their oral pharmaceutical agent AST-004 for the treatment of moderate traumatic brain injury (TBI). The goal is to develop an oral formulation of AST-004 that can improve...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award provides $274,855 to Mito-Biotherapeutics, Inc. to develop a novel fusion protein construct (NFP) that can cross the blood-brain barrier and deliver a therapeutic payload to repair mitochondrial DNA damage in neurons following traumatic brain injury (TBI). The project aims to attenuate neurological damage and prevent the progression of TBI to neurodegenerative diseases like...

This Project Grant award from the National Science Foundation (NSF) Engineering program (CFDA 47.041) will support research to study how astrocytes, a critical cell type in the brain, respond to mechanical forces and strain associated with traumatic brain injury (TBI). The $705,806 award to Tufts University will fund the development of controlled 3D brain-like cell culture environments and ex vivo brain cultures to quantify astrocytes' acute and chronic responses to mechanical perturbation...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $423,500 to The University of Kentucky Research Foundation to examine the role of transforming growth factor-activated kinase 1 (TAK1) in tau pathology following repetitive mild traumatic brain injury (TBI). The research aims to determine an optimal dosage and treatment regimen for the novel small molecule therapeutic BNC-1 to reduce TAK1 phosphorylation and tau pathology, neurodegeneration, and...

The University of Georgia Research Foundation, Inc. (UGA Research Foundation) was awarded a $379,171 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports a 2-year research project to investigate cerebrovascular dysfunction and cerebral atrophy in severe traumatic brain injury (STBI). Specifically, the project aims to: 1) Characterize...

This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...

This federal Project Grant award of $532,385 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports the development and evaluation of a novel targeted nanotherapeutic delivery platform for treating brain disorders. The primary product being developed is a 2-deoxy-D-glucose (2DG)-based glycodendrimer nanoplatform (2DG-D) designed to selectively deliver...

This $453,860 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the metabolic regulation of neutrophil extracellular traps (NETs) in traumatic brain injury (TBI). The grant, awarded to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences, aims to...

This $453,970 Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, will support research by the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. to investigate the effects of intranasal HB-EGF treatment on brain glucose metabolism and inflammation following pediatric traumatic brain injury (TBI). The 2-year project aims to determine if HB-EGF...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $587,521 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the Regents of the University of Michigan to conduct research on "Mitochondrial Modulation Therapy After Brain Trauma". The grant aims to: (1) explore the molecular mechanisms of neurotrauma and the therapeutic effects of near-infrared light on mitochondrial dynamics and turnover, (2)...