Project Grant R44HD118927
- The National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), awarded a $518,754 project grant to Magee-Womens Research Institute and Foundation. The goal of this project is to develop a bioadhesive vaginal film that can provide sustained release of contraceptive and antiviral monoclonal antibodies for 3-7 days. The film is intended to offer women a discreet, low-cost, and convenient...
- This $474,946 Project Grant awarded on February 1, 2025 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to develop a novel, multipurpose device for female-initiated, non-hormonal contraception. The key products to be delivered under this grant include: Design and prototyping of a dual-compartment vaginal device that enables women to administer a bioresponsive polymer fiber mat...
- This Project Grant award of $380,692 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), is for the development of an ultrapotent anti-sperm antibody construct for a non-hormonal contraceptive. The project aims to create a novel intravaginal ring product that releases an anti-sperm antibody to agglutinate and trap sperm, thereby preventing pregnancy. The award supports the...
- This $1,130,880 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a fast-dissolving, non-hormonal contraceptive tablet (product code MM008) by Mucommune LLC, a biopharmaceutical company in Durham, North Carolina. The grant aims to formulate Mucommune's proprietary anti-sperm monoclonal antibodies into a...
- This $747,000 Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to determine the effects of pre-exposure prophylactic (PrEP) drugs on female genital HIV infection and women's reproductive health. The research will focus on understanding how PrEP impacts the female reproductive tract microenvironment and any potential...
- The U.S. National Institute of Child Health and Human Development (NICHD) awarded a $399,999 Project Grant to Sacyl Pharmaceuticals, Inc. under the Child Health and Human Development Extramural Research program (CFDA 93.865) to advance the development of a novel on-demand, non-hormonal male contraceptive towards Investigational New Drug (IND) enablement. The project aims to develop small molecule inhibitors of soluble adenylyl cyclase (ADCY10; SAC) in sperm, which has been genetically and...
- The federal Project Grant award, valued at $743,287.00 and funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a multi-disciplinary research effort to uncover novel insights into endocervical mucus secretion. The primary goal of this 5-year project, which began on May 20, 2025, is to identify the cells and pathways that influence mucus changes in response to hormonal...
- The National Institute of Child Health and Human Development (NICHD), through the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded a $328,496 Project Grant to Pelva Health Corporation to develop a non-pharmaceutical hydrogel film and applicator delivery system to mitigate pain experienced during sexual intercourse by women with gynecological conditions such as vulvodynia and vestibulodynia. The goal is to create a force dissipating hydrogel film that can...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is intended to study the effects of copper versus levonorgestrel intrauterine devices (IUDs) on the mucosal microbiota and barrier function in young African women living with or at risk of HIV. The $751,405 award, granted on September 22, 2025, will fund a randomized trial to be conducted by Seattle...
- The National Institute of Child Health and Human Development (NICHD) awarded a $270,295 Project Grant to Yona Care LLC on September 15, 2025 under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The funding supports the development and assessment of a novel vaginal speculum designed to decrease patient pain and discomfort while enhancing functionality for healthcare providers in outpatient reproductive care. Through a human-centered engineering...
This Project Grant award, provided by the National Institute of Child Health and Human Development (NICHD), is funding a Phase 1 clinical trial to evaluate the safety and pharmacokinetics of a novel contraceptive and microbicidal vaginal gel developed by Yaso Therapeutics Incorporated. The $545,966 award supports the first-in-human clinical assessment of the "YASO-GEL" product, which contains the active ingredient polyphenylene carboxymethylene sodium salt (PPCM). In addition to standard safety and PK evaluations, the trial will assess the gel's impact on the vaginal microbiome and immune factors, as well as its preliminary efficacy in reducing sperm motility, viability, and acrosome loss. The trial will also evaluate the gel's microbicidal activity against Neisseria gonorrhoeae and HIV in ex vivo samples. This funding is provided through the NICHD's Child Health and Human Development Extramural Research program (CFDA 93.865), which supports a broad range of research focused on human development, reproductive health, and pediatric wellness.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/24/25 | ||
| Not listed | $546.0k | 9/11/25 |