Project Grant R44HD116616
- This Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is aimed at developing a sperm-specific epigenetic test to predict the time it takes for couples to conceive. The $306,872 award to Ripple Biosciences, LLC, with a project period from September 2025 to September 2026, will leverage the awardee's machine learning pipeline and existing...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $606,518 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Magee-Womens Research Institute and Foundation. The grant, awarded on June 5, 2025, supports research to develop and test the safety and feasibility of spermatogonial stem cell (SSC) transplantation and testicular tissue grafting techniques for restoring fertility in patients,...
- This National Science Foundation (NSF) Project Grant award of $275,000 to Zealous Research LLC is part of the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop a single-chip microfluidic platform to automate and optimize in vitro fertilization (IVF) processes, including sperm selection, sperm capacitation, and egg fertilization. The goal is to create a user-friendly, affordable, and high-throughput platform that can increase IVF success rates and...
- The federal Project Grant award of $561,097 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research by Yale University to investigate the genetic basis and molecular mechanisms underlying reduced sperm motility, a leading cause of male infertility. The research aims to capitalize on the university's access to large consanguineous Pakistani families with abnormal semen...
- This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", provides $125,814 to support research on quantifying germ cell lineage dynamics in mammalian oogenesis (female egg cell development). The award aims to characterize the process of germ cell selection and the functional importance of early germ cell heterogeneity in shaping the developing ovarian...
- The federal Project Grant award, valued at $743,287.00 and funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a multi-disciplinary research effort to uncover novel insights into endocervical mucus secretion. The primary goal of this 5-year project, which began on May 20, 2025, is to identify the cells and pathways that influence mucus changes in response to hormonal...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,834 to the University of Toledo to study the composition of sperm striated columns and their role in sperm movement and zygote centrosome function. The goal is to identify biomarkers of the striated columns to enable future research on their contributions to male infertility...
- This federal Project Grant award of $108,512 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to investigate the mechanisms by which the salt-inducible kinase 3 (SIK3) regulates fertility and ovarian granulosa cell function. The research focuses on elucidating SIK3's upstream regulation, downstream targets, and role in metabolism during follicle development and granulosa cell...
- The National Institute of Child Health and Human Development (NICHD) awarded a $413,843 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to The Pennsylvania State University, doing business as Penn State, to develop advanced biofabricated seminiferous tubules for in vitro spermatogenesis research. The proposed work aims to use micro-extrusion technology to precisely fabricate microtubes that mimic the cellular composition and organization of in vivo...
- The federal Project Grant award titled "MECHANISMS OF DOUBLE STRAND BREAK REPAIR IN FETAL MALE GERM CELLS" was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $107,458 award, granted on May 1, 2025, supports research at Duke University to determine how male germ cells in the fetal stage repair double-strand DNA breaks and maintain genomic...
This $356,502 federal Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to PS-Fertility, Inc. on September 15, 2025. The grant supports the development and refinement of the PS-DETECT assay, a diagnostic test to quantify the potential fertilization-competent sperm in a semen sample. The overarching goal is to provide clinicians with a new tool to improve assisted reproductive techniques by acquiring better insights into male fertility and sperm function, which is not adequately addressed by conventional semen analysis. The project will establish reference ranges, demonstrate the feasibility of the PS-DETECT assay, and obtain CLIA certification for PS-Fertility, Inc.'s laboratory. This Fast Track SBIR grant is expected to be completed by August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $356.5k | 9/12/25 |