Project Grant R44GM128540

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program provides $350,000 to Electronic Biosciences, Inc., a small biotechnology company in San Diego, California, to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. The proposed technology aims to enable scalable, multiplexed protein sequencing with high accuracy and throughput, surpassing the...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program provides $306,860 to Mixedlcmedia LLC, a small disadvantaged business, to develop and evaluate a prototype ultra-low flow liquid chromatography platform based on their proprietary porous layer open-tubular (PLOT) and monolithic nanocolumn technologies. The goal is to create a commercialization-ready LC system that enables deep proteomic...

This $350,000 Project Grant award from the National Center for Advancing Translational Sciences (NCATS), under the 93.350 CFDA program, supports the development of the Codomax EPI-MAX platform. This integrated omics and computational technology leverages cellular stress responses to enhance the production of difficult-to-express therapeutic proteins, with a focus on improving secretion and preventing aggregation in the Pichia pastoris expression system. The key products or services to be...

Micropure Genomics Inc. received a $274,199 Project Grant award from the National Science Foundation to advance methods for rapid, end-to-end sample preparation for sequencing applications. Under the NSF Technology, Innovation, and Partnerships program (CFDA 47.084), the company will develop an automated process relying on electro-hydrodynamic trapping to isolate genomic material like DNA or RNA from cells in a flow cartridge. The process aims to significantly reduce preparation time while...

This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $283,805 to Invizyne Technologies, Inc. to develop a high-throughput platform for engineering enzymatic group transfer reactions, known as "BioClick" reactions. The project aims to establish a cell-free protein synthesis system and utilize high-throughput experimentation, robotics, and mass spectrometry analysis to...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 Biomedical Research and Research Training provides $350,000 to Fluidispec LLC to develop a new microfluidic/nanofluidic sample preparation platform. The goal is to improve single-cell and low-input proteomics analysis by enabling efficient extraction of proteins from cells, removal of contaminants, and improved protein denaturation. This platform is expected to enhance...

The National Institute of General Medical Sciences (NIGMS) awarded a $3,895,802 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small disadvantaged business. The grant, awarded on August 1, 2024, supports the development of a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities for characterizing charge variants in biologics. The proposed technology...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support a high-risk, high-reward effort to improve the sensitivity and selectivity of laser desorption ionization for mass spectrometry-based proteomics applications. The $247,767 award, effective September 1, 2024 through August 31, 2026, will enable researchers at the University of Notre Dame to develop proof-of-concept experiments...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $387,375 to the University of Texas Medical Branch at Galveston (UTMB) for a research project titled "Protein Turnover Estimation from Fragment Ions and Precursor Enrichment in Heavy Water Labeled LC-MS Experiments". The project aims to develop new techniques to improve the accuracy, throughput, and statistical...