Project Grant R44GM112206

This Project Grant award, provided by the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351), aims to rapidly develop advanced mouse resource strains through the application of Prime Editing technology. The $265,500 award, granted on September 1, 2024, will fund research at the Jackson Laboratory to create a novel combinatorial system that can efficiently modify thousands of mouse genes by applying Prime Editing techniques. The key innovation is the...

This Project Grant award of $275,956 from the National Science Foundation's (NSF) Computer and Information Science and Engineering (CISE) program aims to develop an engineered cyber-physical system that combines advanced biological models with artificial intelligence methods for predictive, automated screening of anti-cancer drugs and optimization of their dosing. The key products and services to be delivered under this award include: 1) Adoption of 3D bioprinting to generate vascularized ductal...

This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $275,000 to Laser Graphictronics LLC, a small disadvantaged business located in Columbia, MO, funds the development of "DigitFOAL", an early labor warning system for safe and successful foal delivery in the equine industry. The project leverages dual wearable photoplethysmography (PPG) sensors and a deep learning algorithm to monitor critical physiological signals in...

This Project Grant award from the National Institutes of Health (NIH) Research Infrastructure Programs (CFDA 93.351) provides $270,428 to TEO Therapeutics Incorporated, a small disadvantaged business, to develop a biomimetic platform for more efficient pharmaceutical drug development in oncology. The key products and services to be delivered include: Refining and testing a proof-of-concept hardware product line for a Shell-Free Quail Xenograft Assay, optimizing throughput and assessing...

This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $240,039 to Baylor College of Medicine to develop a novel mouse model for detecting genome editing events. The project aims to create a more sensitive reporter system based on the Cre-ERT2 recombinase system to improve detection of CRISPR/Cas9-mediated genome editing. This advanced animal model is expected to enable researchers to better evaluate the...

This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) is providing $194,375 to the University of Wisconsin - Madison to develop advanced genome editing tools for the zebrafish model organism. The key products to be delivered include: Establishing a reliable method for generating conditional knockout alleles in zebrafish using a synthetic exon-mediated integration approach to insert LoxP sites. This will enable conditional...

This federal Project Grant award from the National Institutes of Health's Research Infrastructure Programs (CFDA 93.351) provides $235,500 to Cornell University to develop and validate two novel mouse models for compartmentalizing disease pathology and tracing cellular interactions. The first model, called a "Unilateral Mosaic", will express disease-driving genes on one side of the lung only, creating a diseased and disease-resistant internal control in a single animal. The second...

This $254,580 National Science Foundation Technology, Innovation, and Partnerships project grant funds the development of artificial intelligence-mediated orthopedic implant design and selection software by Med Dimensions, LLC. The Phase I small business innovation research project aims to create a machine learning system that incorporates bone density screening and 2D to 3D reconstruction to generate anatomically-derived implants and guide implant placement for veterinary use. By integrating...

This Project Grant award, funded by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351), will provide $1,521,607 to Emory University to acquire an automated robotic culture system for generating, maintaining, and phenotyping organoid models. The goal is to enhance the capabilities of Emory's Organoid Hub, enabling high-throughput and standardized production of various organoid types, including brain, gut, cardiac, and kidney organoids. This automation...

This federal Project Grant award from the National Institutes of Health (NIH) under the Research Infrastructure Programs (CFDA 93.351) provides $349,729 to the Research Foundation For Mental Hygiene, Inc. (RFMH) to acquire and implement specialized digital ventilated caging (DVC) systems for improved monitoring and management of animal models in brain and behavioral research. The DVC systems will enable 24/7 remote monitoring of the cage microenvironment to promote animal health, reduce...