This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides funding of $294,662 to Proteris Biotech, Inc. to support research on using the protein Clusterin (CLU) to treat ocular surface disease and dry eye. The project aims to determine whether CLU can protect the ocular surface epithelia from damage and also have an anti-inflammatory effect in dry eye disease. Recombinant human CLU will be tested for efficacy in a mouse...
This $730,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports the development of an optimized nerve growth factor (NGF) therapeutic called HC201 for the treatment of dry eye disease (DED). The key products and services to be delivered through this funded research project include:
Determining the efficacy and mechanism of action of topical HC201 treatment in improving tear film production and corneal sensitivity compared to...
This $257,785 federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports the development of a refillable, microfabricated lens capsule-based drug delivery device. The key objectives are to: 1) Characterize and control the release of the biologic drug adalimumab from the engineered lens capsule delivery device in vitro and in vivo; and 2) Characterize and control the cell-based production and release of an immune-modulating...
This federal Project Grant award of $332,179 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) is focused on developing sustained-release cysteamine-delivering contact lenses to treat the ocular complications of cystinosis. The key products to be delivered include:
Developing a daily disposable contact lens that can continuously deliver cysteamine for 8 hours, matching the efficacy of the current 8 times daily eye drop regimen, but with improved patient...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports the late-stage preclinical development and GMP production of a novel extended-release intraocular pressure (IOP)-lowering microemulsion formulation containing the FDA-approved drug pregabalin. The award, totaling $1,066,178, will fund studies to optimize and evaluate the IOP-lowering properties and safety of this topical formulation and a subconjunctival biodegradable depot...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $247,500 to Boston University Medical Campus to study the role of limbal fibroblasts in maintaining limbal stem cells for the treatment of limbal stem cell deficiency (LSCD). The key objectives are to reveal the characteristics of limbal fibroblasts and dendritic cells, evaluate their interaction with limbal epithelial cells, and establish a limbal fibroblast injection method to treat LSCD...
This $556,298 Project Grant award from the National Eye Institute (NEI) Vision Research program (CFDA 93.867) aims to establish the feasibility and mechanisms of structural and functional integration of a novel stem cell-derived 3D retinal transplant containing photoreceptors and retinal pigment epithelium (RPE) cells in a minipig model of end-stage macular atrophy. The overarching goal is to develop a cell-based therapy that can restore vision for patients with dry age-related macular...
The National Eye Institute (NEI) awarded a $2,166,307 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the Scripps Research Institute in La Jolla, CA. The 5-year grant, effective June 1, 2024, will investigate the anti-inflammatory mechanisms of calorie restriction in the aging lacrimal gland to address dry eye disease, a prevalent condition impacting millions of elderly adults.
The research aims to elucidate how calorie restriction regulates lipid and...
This National Eye Institute (NEI) Project Grant under the Vision Research program (CFDA 93.867) is providing $792,484 to The Regents of the University of California, San Francisco (UCSF) to conduct key translational studies and explore the roles and mechanisms of the extracellular calcium-sensing receptor (CaSR) in ocular surface health and dry eye disease. The grant will fund research to evaluate CaSR inhibitors in animal and human cell models of dry eye disease, with the goal of advancing a...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $246,000.00 to The Regents of the University of California, San Francisco (UCSF) from January 1, 2025 to December 31, 2026. The project aims to define the combinations of serum components, such as growth factors, signaling lipids, and vitamins, that support corneal repair. The research seeks to determine the bioactive serum tear components and characterize their...
This $356,485 Project Grant award from the National Eye Institute (NEI) under CFDA Program 93.867 (Vision Research) supports Stellular Bio, Inc. in scaling up manufacturing and advancing the company's STLR-201 therapeutic candidate for Sjögren's syndrome-related dry eye disease. The project aims to finalize drug substance processing, establish a scalable manufacturing process, and conduct engineering runs and GMP production to generate product for IND-enabling studies. The STLR-201 therapy is an off-the-shelf, platelet and stem cell-derived regenerative treatment designed to promote corneal epithelial cell proliferation and improve barrier function, offering a potential disease-modifying solution for the approximately 2 million Americans affected by this autoimmune-driven dry eye condition. Successful completion of this Fast-Track SBIR project is expected to position STLR-201 for clinical trials as the first FDA-approved regenerative therapy for Sjögren's syndrome-related dry eye disease.