Project Grant R44DK107094

This Project Grant award of $278,224 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to develop a noninvasive, nonsurgical treatment for large kidney stones using "Burst Wave Lithotripsy" (BWL) technology. The key objectives are to: 1) Fragment 10-20 mm kidney stones in-vitro using a lower 200 kHz BWL frequency, 2) Refine the treatment to further...

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), has awarded a $134,749 Project Grant to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The 5-year grant, effective September 1, 2024, supports the development of a novel nanotechnology-based treatment for kidney stones. The project aims to investigate how gold-based photothermal...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,502 to The Medical College of Wisconsin, Inc. to investigate the protein interactions that control calcium oxalate kidney stone formation. The goal of the research is to understand the mechanisms by which a complex mixture of proteins, including strongly anionic, strongly...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA Program 93.350 provides funding of $437,761 to the University of Texas at Austin for a 2-year research project from August 2024 to July 2026. The project aims to determine if a human enzyme therapeutic that degrades cystine can prevent or slow the formation of cystine kidney stones and mitigate associated kidney pathology in a mouse model of cystinuria, a rare metabolic disorder causing...

This Project Grant award of $3,834,661 from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) to the University of Washington will fund a 4-year study on nonsurgical kidney stone removal in persons with spinal cord injury. The study aims to develop innovative techniques to improve care and outcomes for this patient population. As the prime recipient, the University of Washington will lead the research activities. No additional details were provided on...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $398,487 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to Vanderbilt University to develop and validate a gaze-based training system for endoscopic kidney stone surgery. The project aims to create an eye gaze-based guidance system that can improve surgeon training and stone visualization during endoscopic kidney stone procedures, which currently...

This Project Grant award of $294,641 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is supporting the development of a low-cost ultrasound imaging system that can be operated by untrained users. The small business awardee, Sonovance, Inc., is working to optimize and validate their patented system for guiding unskilled operators to obtain acceptable diagnostic...

The federal Project Grant award with ID P20DK140504 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The overarching objective of the $1,266,104 "Personalizing Outcomes of Nephrolithiasis in Youth (PONY)" P20 Center is to generate knowledge that improves outcomes for youth with kidney stone disease (nephrolithiasis) by accelerating the research...

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to leverage a unique dog model to investigate the role of the protein uromodulin in kidney stone disease. The $368,500 award, effective September 1, 2024 through August 31, 2025, will support research to identify how defects in uromodulin polymerization and peptide excretion impact renal...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,543,110 to New York University School of Medicine to investigate the role of the gut microbiome in determining urine oxalate levels. The research aims to better understand how gut microbial metabolism of dietary oxalate is linked to urinary oxalate levels, with the goal of...