This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,502 to The Medical College of Wisconsin, Inc. to investigate the protein interactions that control calcium oxalate kidney stone formation. The goal of the research is to understand the mechanisms by which a complex mixture of proteins, including strongly anionic, strongly...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $200,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Washington University in St. Louis. The goal of this R56 award is to delineate the molecular mechanism regulating autophagy in Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD) caused by UMOD mutations. The university will use CRISPR/Cas9 technology to generate the first...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), has awarded a $134,749 Project Grant to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The 5-year grant, effective September 1, 2024, supports the development of a novel nanotechnology-based treatment for kidney stones. The project aims to investigate how gold-based photothermal...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to better understand the role of the gut microbiome and other host factors in determining urine oxalate levels. The $1,543,110 award to New York University School of Medicine will support a multidisciplinary investigation spanning computational analysis, animal studies, and leveraging data from large...
This federal Project Grant award for $153,540 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at Columbia University to perform human genome-wide association studies (GWAS) to identify genetic risk variants associated with urinary tract infections (UTIs). The research aims to discover novel genes and cell types involved in immune...
This Project Grant award of $532,177 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to investigate a new inflammation pathway in diabetic kidney disease (DKD). The University of North Texas Health Science Center at Fort Worth will conduct in vitro and in vivo studies to: 1) determine how the transcription modulator I-MFA stimulates inflammatory cytokine production in...
This $577,420 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to provide a mechanistic framework for understanding upper urinary tract (UUT) physiology. The grant supports research conducted by Weill Medical College of Cornell University to define the transcriptional signaling mechanisms and protein complexes required for UUT pacemaker formation and functional...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $3,202,605 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Vanderbilt University Medical Center (VUMC) to create the Urinary Stone Disease Hub (USDHUB). USDHUB will be a comprehensive research resource to support a wide range of clinical investigations aimed at improving care and outcomes for individuals with urinary stone disease across the...
This $492,329 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the FBW7 gene in the development of cystic kidney diseases. The project aims to enhance understanding of the cellular mechanisms driving cyst formation, fibrosis, and tubular degeneration, with the goal of identifying new therapeutic targets...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $199,999 to the University of Florida to develop innovative artificial intelligence (AI)-based methods to support the discovery of potent, orally available small-molecule heparanase inhibitors. The goal is to evaluate these novel heparanase inhibitors in murine models as a...