This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to leverage a unique dog model to investigate the role of the protein uromodulin in kidney stone disease. The $368,500 award, effective September 1, 2024 through August 31, 2025, will support research to identify how defects in uromodulin polymerization and peptide excretion impact renal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), has awarded a $134,749 Project Grant to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. The 5-year grant, effective September 1, 2024, supports the development of a novel nanotechnology-based treatment for kidney stones. The project aims to investigate how gold-based photothermal...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $434,502 to The Medical College of Wisconsin, Inc. to investigate the protein interactions that control calcium oxalate kidney stone formation. The goal of the research is to understand the mechanisms by which a complex mixture of proteins, including strongly anionic, strongly...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $223,918 to the University of Oklahoma Health Sciences Center to study "Targeting Kidney Resident Macrophage Niche Filling to Slow Cystic Kidney Disease". The project aims to understand the mechanism of kidney resident macrophage (KRM) niche filling after temporary depletion and identify factors like...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $2,029,830 to the University of Utah to conduct research on the structural mechanisms and functional properties of polycystin proteins associated with polycystic kidney disease, biliary atresia, and congenital heart defects. The key objectives are to: 1) determine the structures and stoichiometry of various...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is funding research to develop a therapeutic approach using dicarboxylic acids (DCAs) to prevent and treat acute kidney injury (AKI) and limit progression to chronic kidney disease (CKD). The $645,599 award to the University of Pittsburgh is supporting preclinical studies in animal models...
This Project Grant award under the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) will provide $410,000.00 to The University of Texas Southwestern Medical Center to conduct research on the regulation of the phosphate transporter SLC20A1. The research aims to examine the mechanisms governing SLC20A1 internalization, degradation, recycling, and synthesis in order to better understand phosphate sensing and homeostasis in...
This federal Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), aims to better understand the role of the gut microbiome and other host factors in determining urine oxalate levels. The $1,543,110 award to New York University School of Medicine will support a multidisciplinary investigation spanning computational analysis, animal studies, and leveraging data from large...
This $199,990 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at The Ohio State University to investigate the role of the transcriptional corepressor CTBP2 as a metabolic sensor in acute kidney injury (AKI). The key objectives are to: 1) examine how acetylation regulates the nuclear localization and activation...
This Project Grant award of $3,834,661 from the Department of Defense's Military Medical Research and Development program (CFDA 12.420) to the University of Washington will fund a 4-year study on nonsurgical kidney stone removal in persons with spinal cord injury. The study aims to develop innovative techniques to improve care and outcomes for this patient population. As the prime recipient, the University of Washington will lead the research activities. No additional details were provided on...