This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $306,200.00 to The Catholic University of America (CUA) to conduct research on molecular mechanisms of damage and repair in an oral mucosa chip. The key objectives of this 2-year project are to: 1) Determine the effects of chemotherapy drugs and fractionated radiotherapy on cell layer morphology, reactive oxygen,...
This $622,744 Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) supports research to investigate the role of the TRPM2 calcium channel in the development of radiation-induced oral mucositis (RIOM). The University of Texas Health Science Center at San Antonio is conducting this 5-year research project to understand how TRPM2 activation and calcium signaling contribute to...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
This $799,270 federal project grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support the development of a novel class of anticancer drugs called 1,3-thioureas for the treatment of oral squamous cell carcinoma (OSCC). The grant recipient, Keraceuticals, Inc., will focus on formulating the lead compound CIDD99 for oral and/or intravenous administration, evaluating its efficacy in mouse...
This $245,504 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop new transgenic mouse models and conduct pre-clinical evaluation of a small molecule inhibitor targeting the replication protein A (RPA) complex. The research focuses on enhancing treatment responses for oral squamous cell carcinoma (OSCC) by exploiting the stress-specific functions of RPA. Key...
This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to improve understanding of oral cancer pain mechanisms. The $162,743 award will support research to develop and validate assays for measuring pressure and stretch sensitivity in oral cancer, as well as leveraging genetically engineered mice to study the role of the TRPV4 ion channel in Schwann cells and...
This federal Project Grant award of $274,100.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance understanding of pain signaling and drug delivery for treating oral cancer pain. The key objectives are to: Determine the impact of oral cancer on the trafficking and signaling of the protease-activated receptor 2 (PAR2) in trigeminal neurons. This will involve investigating changes in PAR2...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $704,206 to Oregon Health & Science University (OHSU) to develop an "organ on-a-chip" model of oral cancer and bone invasion. The goal is to systematically manipulate, characterize, and validate tissue microenvironment variables linked to oral squamous cell carcinoma (OSCC) invasion into bone, elucidate...
This federal Project Grant award of $1,178,476 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop an AI-linked cytomics-on-a-chip technology to enable early identification and management of oral lichenoid lesions in primary care settings. The project, conducted by Oraliva, Inc., seeks to advance a point-of-care tool that can accurately distinguish between benign, pre-cancerous, and...
This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...