Project Grant R44AG097355
- This Project Grant award of $717,709 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to discover cellular mechanisms underlying the propagation of misfolded tau protein aggregates in human neurons, which are key drivers of cognitive decline in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The research combines advanced proteomic techniques, deep learning analyses, and transcriptomic profiling using newly generated human induced pluripotent stem...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Jillion Therapeutics Inc. aims to identify small molecule compounds that can bind to and modify the biological behavior of tau protein, which is implicated in Alzheimer's disease and other neurodegenerative "tauopathies". The $496,373 award, spanning September 2024 to August 2025, will utilize the company's DNA-encoded library (DEL) drug discovery platform to screen a large chemical...
- This $816,661 Project Grant award, issued on June 1, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research program), supports comprehensive research aimed at elucidating the molecular mechanisms underlying tauopathies such as Alzheimer's disease and frontotemporal dementia. The project, titled "Aberrant Proteomes in Tauopathy: Revealing Functional Consequences via Multimodal Proteomics", combines expertise in mass spectrometry-based proteomics and functional genomics to...
- This Project Grant award, with a total funding amount of $431,750, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award is for the development and evaluation of a novel immuno-gene therapy approach using a single-chain fragment variable (scFv) derived from an anti-tau oligomeric complex 1 (TOC1) antibody. The key objectives are to: 1) generate and validate the TOC1-scFv-HaloTag-Proteasome Degradation Signal (PDS)...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,336,256.00 to the University of Illinois to develop small molecule ligands that target pathological tau signaling in Alzheimer's disease and related dementias. The research aims to identify candidate molecules that can block the toxic effects of misfolded tau protein, which is a key driver of neurodegeneration in these diseases. The grant will fund the screening and initial optimization of...
- This $519,750 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 2-year research study by the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco. The study aims to explore the underlying molecular mechanisms by which reducing levels of the tau protein can prevent or diminish excitation/inhibition imbalance and network hyperexcitability in the brain. This imbalance has been observed in various...
- This $784,596 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports comprehensive proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease and tauopathy models. The project aims to develop a proteogenomic pipeline to globally characterize disease-associated proteins with amino acid substitutions, alternative isoforms, post-translational modifications, and proteolytic cleavages across multiple brain...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $433,125 will fund a study to investigate the relationship between microglia, neurons, and tau pathology in Alzheimer's disease. The research will utilize a novel model system of microglial co-cultures with hippocampal assembloids derived from patient-derived induced pluripotent stem cell (iPSC) lines with MAPT mutations and healthy controls. The goal is to explore how bidirectional changes...
- This federal Project Grant award of $734,778 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the Regents of the University of Minnesota. The award supports the development and evaluation of human induced pluripotent stem cell (iPSC)-derived chimeric antigen receptor (CAR) macrophages to target the pathogenic tau protein and modulate inflammation in Alzheimer's disease and related dementias. Key activities include engineering and testing...
- This federal Project Grant award of $437,250.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development of new imaging tools to study the various forms of the tau protein, which is implicated in Alzheimer's disease. The goal is to create a peptide-based probe that can detect tau in its soluble, liquid-liquid phase separation, and liquid-solid phase separation states within living cells using an aggregation-induced emission (AIE) approach. This...
This Project Grant award of $1,257,528 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Novoron Bioscience Inc. is focused on developing a platform to evaluate novel therapies designed to inhibit the propagation and aggregation of pathological tau protein, which is a key driver of Alzheimer's disease and other tauopathies. The platform will leverage human induced pluripotent stem cell (hiPSC)-derived neural organoids, including both wild-type and LRP1 knockout organoids, to model tau pathology and screen compounds that can disrupt tau propagation. This multi-faceted approach aims to identify and validate candidate therapeutics that could lead to new treatments for Alzheimer's and related dementias. The award period runs from September 2025 through May 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/16/25 |