Project Grant R44AG090130
- This Project Grant award of $500,000 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to support the development of an in vivo imaging platform called the VasoVue Lab. The objective is to enable rapid, non-invasive assessment of cerebrovascular dysfunction, which is known to be impaired in Alzheimer's disease (AD). The proposed solution will use laser speckle contrast imaging to monitor blood flow changes in the retina and brain...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
- The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
- The National Institute on Aging (NIA), through its Aging Research federal grant program (CFDA 93.866), awarded the University of Washington a $303,614 Project Grant (R03AG081836) to develop a computational model for accurately calculating cerebrospinal fluid (CSF) velocities and brain tissue deformation. The goal is to create novel, non-invasive biomarkers for early detection of Alzheimer's disease by measuring impairment of CSF flow and brain tissue stiffness, which are linked to the...
- The National Institute on Aging (NIA) has awarded a $640,906 project grant under CFDA 93.866 Aging Research to the University of Wisconsin-Madison to conduct research on "Elucidating Cerebrovascular Disease Pathways to Cognitive Decline with Vascular Neuroimaging." The 5-year project aims to utilize advanced neuroimaging techniques to understand the vascular contributions to cognitive impairment and dementia (VCID), and assess their relationship to Alzheimer's disease proteinopathy....
- The National Institute on Aging (NIA) awarded a $1,783,700.00 Project Grant under the Aging Research program (CFDA 93.866) to the University of Illinois to develop novel blood-brain barrier permeable multimodal imaging agents for the diagnosis of neurodegenerative diseases, with a focus on Alzheimer's disease and related dementias. The 3-year grant aims to employ organic and inorganic chemical design principles to generate diagnostic agents capable of detecting protein aggregation,...
- The National Institute on Aging (NIA) awarded a $397,902 Project Grant to Panluminate Inc., a woman-owned small business in Connecticut, to develop FLASH-PULSE, an automated and multiplexed imaging solution for rapidly mapping the distribution of specific cell markers within tissue samples at the subcellular scale. The project aims to create a microfluidics-based system and novel probes to enable 32-plex protein imaging of formalin-fixed paraffin-embedded (FFPE) tissue samples without the need...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded Aivocode, Inc. a $1,244,775 project grant to develop single domain antibodies targeting Connective Tissue Growth Factor (CTGF) for improving vascular dysfunction in Alzheimer's disease. The award period runs from September 2025 to May 2027. The funding will support preclinical research to test these single domain antibodies in mouse models of Alzheimer's disease, with the goal of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $499,588 to develop non-radioactive nanoprobes for magnetic resonance imaging (MRI) of tropomyosin receptor kinase B (TrkB) in Alzheimer's disease. The goal is to create new MRI-based imaging tools to detect reduced TrkB expression, which is linked to impaired neurogenesis, synaptic damage, and neuronal death in Alzheimer's. The award recipient, Exqor Technologies Inc., will work to create a...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded Translucence Biosystems, Inc. a $1,025,651 Project Grant to develop and qualify a Vasculature Subtraction Parenchymal Quantification (VSPQ) workflow. The VSPQ workflow aims to enhance Translucence Biosystems' proprietary 3D brain imaging and analysis platform to precisely measure the distribution of antibody-based therapeutics within the brain parenchyma, addressing a key technological shortfall in accurately assessing blood-brain barrier penetration. The project, awarded on September 20, 2025, is scheduled for completion by May 31, 2027. Translucence Biosystems, a neuroscience technology company based in Irvine, California, will leverage its expertise in artificial intelligence, machine learning, and advanced imaging techniques to deliver this enhanced 3D brain analysis capability for the NIA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 9/19/25 |