Project Grant R43AG092073
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $312,148 to Panluminate Inc., a woman-owned small business, to develop AFLEX, an automated and multiplexed imaging solution for rapid, high-throughput spatial proteomics analysis of formalin-fixed, paraffin-embedded (FFPE) tissue samples. The project aims to (1) develop a new microfluidics prototype tailored for FLASH tissue samples, (2)...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,416,590 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Panluminate Inc., a woman-owned small business based in Connecticut. The grant, with a period of performance from August 6, 2025 to June 30, 2027, aims to develop an automated fluidics light sheet microscope and AI-driven image analysis software to enable high-resolution 3D imaging and characterization of mitochondrial...
- This $499,588 Project Grant was awarded on September 22, 2025 by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to Exqor Technologies Inc., a small disadvantaged business located in Boston, MA. The goal of this project is to develop non-radioactive nanoprobes that can be used for magnetic resonance imaging (MRI) of the tropomyosin receptor kinase B (TrkB) protein, which is implicated in the pathology of Alzheimer's disease (AD). The...
- The University of Illinois has been awarded a $1,870,822 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to develop new super-resolution fluorescence microscopy techniques. The goal is to achieve ultra-high resolution imaging of native amyloid-alpha receptors (AMPARs) in brain slices to study synaptic plasticity in both healthy and tauopathy conditions. The research will utilize multi-color imaging and digital image reconstruction methods to isolate...
- The National Institute on Aging (NIA), through its Aging Research Federal Grant Program (CFDA 93.866), awarded a $498,366 Project Grant to the University of California, San Diego (UCSD) to develop a platform for high-resolution imaging of peripheral blood mononuclear cells (PBMCs) to assess biological age. The project aims to pioneer the use of imaging-based chromatin and epigenetic age (IMAGE) analysis to capture changes in the spatial organization of chromatin and epigenetic marks that...
- This Project Grant award of $493,384 from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research supports the development and validation of an eyedrop-based diagnostic test for Alzheimer's disease (AD). The funding will enable Tauvision, Inc., a small for-profit business, to optimize a fluorescent dye compound that can label AD-related protein aggregates in the eye, allowing non-invasive imaging and measurement of AD biomarkers using standard ophthalmology equipment. In Phase...
- This $850,740 project grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to significantly expand fluorescence spectral multiplexing in tissue imaging. The grant recipient, Lamprogen, Inc., will develop a 56-color panel of semiconducting polymer dots (PDots) with narrow absorption and emission bands. This will enable 56-plex imaging to deeply profile immune cells in tissue samples, as well as...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- This Project Grant award of $306,871.00 from the National Institute on Aging (NIA) under CFDA 93.866 (Aging Research) supports the development and commercialization of Fluid Discovery's "FIND-SEQ" technology. FIND-SEQ is a novel cell sorting platform that enables the isolation and profiling of rare cell types, such as pathogenic astrocytes, from primary human tissues even when no known surface markers are available. This Fast-Track SBIR grant will fund the translation of FIND-SEQ...
- The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $397,902 to Panluminate Inc., a woman-owned small business, to develop and validate a versatile multiplexed tissue imaging solution called FLASH-PULSE. The project aims to create an automated, microfluidics-based system that enables rapid, 32-plex protein imaging of large tissue sections (up to 1 cm2) from formalin-fixed, paraffin-embedded (FFPE) samples. Key objectives include developing a new microfluidics concept to eliminate the need for traditional bulky equipment, creating novel FLASH probes for high-quality imaging in FFPE tissues, and testing the FLASH-PULSE system on aged and young human lymphoid tissue samples. The project will advance Panluminate's efforts to widely disseminate this innovative spatial proteomics technology to research and biotech labs globally.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $397.9k | 9/19/25 |