Project Grant R43NS141467
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research to develop a novel gene therapy approach to reduce neurotoxicity in Parkinson's disease. The $1,009,212 award to the Van Andel Research Institute in Grand Rapids, MI will fund pharmacodynamic, pharmacokinetic, and in vivo efficacy studies to enhance the activity of the...
- This $616,200 Project Grant was awarded on February 1, 2025 by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to explore the influence of neuromelanin, a dark pigment, on dopaminergic neurons in Parkinson's disease. The project aims to develop a novel mouse model that accumulates neuromelanin in dopamine neurons to study the resulting...
- This $475,475 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The goal of the award is to evaluate a small molecule inhibitor of the USP30 enzyme as a potential neuroprotective therapy for Parkinson's disease. The research will assess...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $646,104 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the San Diego Biomedical Research Institute, a non-profit research organization. The grant supports research to investigate how neuroinflammation mediated by the interleukin-13 receptor signaling pathway may contribute to the selective loss of dopaminergic neurons in Parkinson's disease. The...
- This federal Project Grant award of $220,260.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The purpose of the grant is to investigate the role of the RNA-binding protein ELAVL3 in regulating glutamate and dopamine receptor signaling in the striatal neurons of the brain, with the goal of understanding the molecular mechanisms underlying striatal...
- This Project Grant award of $422,125 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund research to investigate the fundamental roles of the DNAJC12 protein in dopamine production and brain function. The research aims to specifically ablate DNAJC12 in dopaminergic neurons in order to ascertain the effects of this gene dysfunction on dopamine synthesis,...
- This Project Grant award, totaling $684,451, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The primary objective is to develop an integrative machine learning pipeline to identify Parkinson's disease (PD) progression subtypes and potential drug targets through analysis of longitudinal clinical, transcriptomic, and neuroimaging data. Key...
- This $112,158 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify changes in basal ganglia neural activity associated with depression in Parkinson's disease (PD) patients. The research aims to determine the specific brain regions and networks involved, as well as evaluate the effects of deep brain stimulation (DBS)...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is providing $647,116 to the Regents of the University of Michigan to characterize and target a novel pathway promoting Parkinson's disease (PD) and Parkinson's disease dementia (PDD). The funded research aims to investigate how the interaction between the protease tissue...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is funding research at the University of Alabama at Birmingham (UAB) to investigate the epigenetic and cellular mechanisms underlying levodopa-induced dyskinesia (LID), a debilitating motor side effect of Parkinson's disease medication. The $350,036 award, granted on June 18,...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Eikonizo Therapeutics, Inc. to develop next-generation histone deacetylase 6 (HDAC6) inhibitors for the treatment of Parkinson's disease. The $499,766 award, active from August 1, 2025 to July 31, 2026, aims to evaluate the efficacy of Eikonizo's development candidate EKZ-102 in reducing Parkinson's disease pathological markers and improving dopaminergic neuron survival in in vitro and in vivo models. The successful completion of this project is expected to validate the disease-modifying potential of Eikonizo's novel HDAC6 inhibitors for Parkinson's therapy.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $499.8k | 7/31/25 |