This Project Grant award, with ID R01NS141959, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The goal of the research is to investigate the cellular and molecular changes that occur in a specific subset of neurons (D1-MSNs) in response to levodopa treatment over the course of developing levodopa-induced dyskinesia (LID), a debilitating side effect of Parkinson's disease medication. The $350,036 award, with a project period from June 18, 2025 to May 31, 2030, will be conducted by the University of Alabama at Birmingham, a leading academic medical center with extensive biomedical research capabilities. The research aims to establish an "engram-like" population of D1-MSNs and utilize a transcription-to-behavior approach to study the epigenetic mechanisms, cellular connectivity, and behavioral outcomes underlying the development of LID. The findings are expected to identify potential targets for therapies to mitigate LID and prolong the usefulness of levodopa, the gold standard treatment for Parkinson's disease.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $350.0k | 6/18/25 |