Project Grant R43NS092182

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is providing $426,938 to Virginia Commonwealth University to explore the role of a novel glutamate-driven signaling pathway initiated in maturing oligodendrocytes through the glutamate transporter GLT-1/EAAT2. This research aims to characterize the mechanisms downstream of...

Federal Project Grant Award Summary Research Triangle Institute (RTI International) received a $547,846 Project Grant from the National Institute of Neurological Disorders and Stroke under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), awarded on August 1, 2025, with a completion date of July 31, 2027. The award supports the optimization and characterization of small molecule GPR17 (G protein-coupled receptor 17) antagonists as potential...

Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a $427,104 project grant effective September 23, 2025, through August 31, 2027, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This R21 exploratory research grant supports the identification of novel biomarkers associated with demyelination and remyelination in multiple sclerosis (MS) using central nervous...

Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Johns Hopkins University a $439,027 Project Grant effective July 8, 2025, through April 30, 2030, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). This research initiative investigates the role of indole lactate (ILA), a gut microbiota-derived metabolite, in promoting myelin repair and remyelination in multiple sclerosis (MS)....

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, is focused on developing a novel drug candidate to treat demyelinating neuropathies. The $352,073 award will support rigorous in vivo testing of the experimental ABCA1 agonist drug, CS6253, in validated mouse models of hereditary peripheral nerve disorders characterized by impaired...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $184,837 Project Grant titled "Promoting Spinal Cord Repair Using a Polymer-Based Drug Delivery System" to The Ohio State University on April 25, 2025. This grant, funded under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to explore the use of a polymer-based drug delivery system to promote axon regeneration and functional recovery...

Renerva LLC, a for-profit manufacturer, is developing peripheral nerve matrix (PNM) technologies to facilitate functional recovery in animal models of direct muscle neurotization (DMN) through a $494,955 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The two-year project aims to 1) optimize the formulation of a clinical-grade PNM product to provide...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $151,559 to Rensselaer Polytechnic Institute (RPI) from August 3, 2024 to July 31, 2026. The project aims to develop innovative magnetically responsive drug delivery electrospun fibers to improve regeneration after spinal cord injury (SCI). Specifically, the research will focus...

The Johns Hopkins University was awarded a $982,500 Project Grant from the Department of the Army Medical Command under the Military Medical Research and Development program. The grant will fund preclinical studies of Bryostatin-1 to promote remyelination and repair in multiple sclerosis from July 15, 2021 to July 14, 2024. Through this funding, The Johns Hopkins University will investigate medical solutions for the battlefield by conducting applied and advanced biomedical research into...

This $570,362 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) is funding research to evaluate the disease-modifying potential of dimethyl fumarate (DMF) for preventing and treating pharmacoresistant epilepsy. The research aims to determine the pharmacokinetic/pharmacodynamic relationship of DMF, demonstrate stable blood and brain levels using an...