This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $390,000.00 to the University of Texas at Dallas to conduct research on translational control in focal cortical malformations and epilepsy. The research aims to determine the specific mRNA subsets altered due to dysregulated MNK-eIF4E signaling, delineate the contribution...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $426,250 Project Grant under CFDA 93.853, Extramural Research Programs in the Neurosciences and Neurological Disorders, to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 2-year grant will fund research using cutting-edge voltage imaging to examine how interactions between specific neuronal circuit elements in the hippocampus relate to the development of temporal lobe...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", will fund research to develop improved screening methods for new anti-seizure medications using a Drosophila (fruit fly) model of pharmacoresistant epilepsy. The $363,602 award, effective January 21, 2025 through December 31, 2025, will support two phases of work: 1) enhancing the existing...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $376,355.00 to Albany Medical College to investigate the role of microglial insulin-like growth factor 1 (IGF1) in epileptogenesis. The research aims to characterize how elevated mTOR signaling in microglia leads to increased IGF1 expression, which then propagates mTOR signaling to...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $234,276 over 5 years to the University of California, San Diego (UCSD) to conduct research on predicting outcomes for epilepsy surgery. The project aims to use functional MRI (fMRI) and advanced statistical/machine learning methods to identify associations between brain network...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $129,454 to the University of Maryland, Baltimore to study the role of the SUR1-TRPM4 channel in chronic seizure susceptibility. The research aims to define how neuronal expression of this channel contributes to hyperexcitability and seizure activity, with the goal of...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the molecular mechanisms by which the glucocorticoid receptor (GR), cytochrome P450 (CYP), and P-glycoprotein (P-gp) axis regulates antiseizure medication (ASM) bioavailability across the blood-brain barrier in epilepsy with focal cortical dysplasia. The...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will provide $225,400.00 over 5 years starting January 1, 2025 to The Regents of the University of California, San Francisco (UCSF). The project aims to investigate hippocampal-cortical neuronal mechanisms underlying memory impairment in temporal lobe epilepsy. Specifically, it will use...
The federal Project Grant award of $657,958.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at Trustees of Boston University to investigate the cellular and network mechanisms underlying epileptic activity and seizures. The research aims to elucidate the neuronal mechanisms of biomarkers associated with epilepsy, such as spike ripples, and gain...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,569,716 to Emory University to conduct research aimed at deconstructing the antiseizure mechanisms of anterior thalamic nucleus electrical stimulation (ANT-DBS) for treating drug-resistant epilepsy. The key objectives are to identify the neuronal network components that...