The National Human Genome Research Institute (NHGRI) awarded a $1,033,069.24 Project Grant (CFDA 93.172 - Human Genome Research) to The Johns Hopkins University to develop novel statistical methods for data integration across disparate datasets in genetic and epidemiologic studies. The project aims to: Create a framework for building generalized linear models using detailed covariate data from a main study while incorporating summary statistics from an external study, with applications to...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) will provide $478,037 to a collaborative research partnership between Henry Ford Health and Michigan State University Health Sciences. The goal of this 2-year project is to develop novel transfer learning algorithms to improve the accuracy of polygenic risk scores (PGS) for ancestry groups underrepresented in genomics research. The researchers will benchmark penalized and Bayesian...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) is focused on developing and applying machine learning-based approaches to estimate disease risk in diverse and admixed populations. The $399,156 award to Galatea Bio Inc., a minority-owned small disadvantaged business located in Miami Lakes, FL, will support the following key objectives over the project period from September 2024 to August 2025: Evaluating the performance of existing...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop novel statistical models for multi-trait analysis in large-scale biobank datasets linked to electronic health records. The $122,234 award, effective from September 20, 2024 to August 31, 2026, will support research at Columbia University's Health Sciences Division to enhance disease association mapping and risk prediction accuracy. Specifically, the project will: 1)...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to integrate genetic and socio-environmental factors to predict disease progression. The $138,499 award to The General Hospital Corporation (doing business as Massachusetts General Hospital) aims to develop statistical models that leverage genetic, longitudinal healthcare, and socio-environmental data to enhance precision medicine for 16 exemplar disease...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $1,341,011 Project Grant to the University of Pittsburgh to develop a novel computational framework that integrates deep learning and causal discovery algorithms. The goal is to unveil individualized cell-cell communication networks underlying tissue environment heterogeneity across normal and disease conditions. The framework will leverage single-cell...
This federal Project Grant award of $246,776.00 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop novel methods for creating and validating polygenic scores (PS) that can predict medication response in African American populations. The goal is to create ancestry-robust PS tools that account for local genetic ancestry context, improving their predictive performance for non-European populations. The...
This Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to develop novel computational methods for integrating large-scale genomic datasets to better understand the regulatory networks underlying complex human traits and diseases. The $533,801.84 award, effective September 18, 2024 through June 30, 2027, will enable the awardee, The Trustees of the University of Pennsylvania, to: 1) improve causal structure learning...
The National Human Genome Research Institute (NHGRI), under the Human Genome Research Federal Grant Program (CFDA 93.172), awarded a $130,680 Project Grant to The Children's Hospital Corporation (doing business as Boston Children's Hospital) for the period of July 1, 2025 to June 30, 2027. The grant will fund the development of robust computational technologies for single-cell functional genomics, enabling the comprehensive identification of genetic variants (SNPs) that regulate tissue niches...
This Project Grant award, valued at $491,366, was issued by the National Human Genome Research Institute (NHGRI) under the Human Genome Research federal grant program (CFDA 93.172). The award is focused on developing new algorithms to robustly map disease-associated genetic variants to critical target genes, particularly in underrepresented populations. Key objectives include: Improving the ability to identify disease-critical genes in non-European populations where data is limited. Developing...
This Project Grant award from the National Human Genome Research Institute (NHGRI), under the federal Human Genome Research grant program (CFDA 93.172), is focused on enhancing the interpretability and applicability of polygenic scores through the integration of multi-omics data and family-based studies. The primary objectives are to: 1) develop machine learning approaches to integrate genetic, multi-omics, and environmental data to construct partitioned polygenic scores representing distinct functional pathways, 2) create likelihood-based methods to estimate causal effects of multiple exposures on diseases in family-based studies, and 3) identify heterogeneous causal effects of exposures using the partitioned polygenic scores. The total funding for this award is $110,161, with a performance period from September 19, 2024 to August 30, 2026. The project will be conducted by The Johns Hopkins University, a leading research institution known for its expertise in biomedical research, public health, and scientific analysis.