This $437,931 Project Grant was awarded by the National Institutes of Health (NIH) under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Chicago. The grant will fund a 4-year research project to develop novel methods for integrating multi-tissue expression quantitative trait locus (eQTL) and methylation QTL (mQTL) data to improve detection of genetic regulatory mechanisms underlying complex traits and diseases. Specifically, the project aims to: 1)...
This federal Project Grant award, totaling $491,366, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research (CFDA 93.172) program. The grant supports research by the University of California, San Diego to develop new algorithms for robustly mapping disease-associated genetic variants to critical disease genes, with a focus on identifying target genes in understudied non-European populations. The research aims to uncover the mechanistic links...
The National Human Genome Research Institute (NHGRI) awarded a $1,350,896 Project Grant (CFDA 93.172 - Human Genome Research) to the University of California, San Diego to develop novel technology for studying how regulatory DNA sequences control gene transcription. The goal is to create a "multimodal MPRA platform" that can simultaneously measure the effects of regulatory sequence perturbations on chromatin state, protein-DNA interactions, 3D chromatin interactions, and...
This federal Project Grant award of $757,157, provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), supports the development of complementary experimental and computational strategies for high-throughput characterization of the impact of genetic variants on key regulatory and DNA repair genes. The award will fund the creation of SCBE-SEQ, a technology that combines pooled genome editing with single-cell sequencing to...
This $409,896 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of new statistical methods and analyses to leverage functional genomics data, in conjunction with genome-wide association study (GWAS) data, to better understand the functional effects of genetic variants and their roles in human diseases. The key objectives of this 5-year research program are to: (i) identify...
This $363,057 five-year project grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support research to understand the genetic pathways that regulate DNA methylation and gene expression in human cells. The principal investigator's laboratory at the University of California, Berkeley will use genome-wide genetic screens to identify new genetic factors involved in DNA methylation, and then...
This $478,037 Project Grant awarded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop novel transfer learning algorithms to improve the accuracy of polygenic scores (PGS) for predicting phenotypes and disease risk in ancestry groups underrepresented in genomics research. The key objectives are: 1) Developing and benchmarking penalized regression and Bayesian regression methods that leverage external estimates of SNP effects (e.g., from...
This $2,293,200 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) aims to develop a novel "Transcriptional Endpoint Marking" (TEM) technology. The TEM approach will introduce permanent genetic markers at the loci of actively transcribed genes, enabling a comprehensive record of a cell's transcriptomic profile and developmental history. The 5-year project, beginning July 1, 2024, will provide proof-of-concept for this...
This federal Project Grant award, valued at $119,611 and awarded by the National Human Genome Research Institute (NHGRI), is focused on "Using the Continuum of Genetic Causality to Investigate Trans Regulatory Mechanisms." The overarching goal is to uncover regulatory networks controlled by monogenic disease-associated transcription factors and decipher their involvement in processes that drive complex disease phenotypes. The key research activities to be conducted under this CFDA...
This Project Grant award of $1,203,750.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to understand the mechanisms that regulate and coordinate the expression of DNA methylation "writer" and "eraser" genes to maintain epigenetic homeostasis. The primary awardee, The Regents of the University of California, doing business as UC Berkeley, will perform a...