The National Institute of General Medical Sciences (NIGMS) awarded a $468,872 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to the University of California, Los Angeles (UCLA) to conduct research aimed at harnessing the unique properties of fluorine for advanced biomaterials and biotechnologies. The key products and services to be delivered under this 5-year grant include: Designing cyclophane host molecules that can recognize perfluorinated aromatic compounds in living...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program, is focused on developing new methods for rapid access to Positron Emission Tomography (PET) imaging agents through metal-mediated C-H radiofluorination. The $505,848.59 award, with a project period from September 1, 2024 to August 31, 2027, aims to optimize amide C-H...
The National Institute of Child Health and Human Development (NICHD) awarded a $295,923 Project Grant to Biostrategies LC under the Child Health and Human Development Extramural Research program (CFDA 93.865). The purpose of the award is to develop a "delivery-enhanced" gene therapy drug comprising an RTB:GALNS fusion protein for treating the rare metabolic disorder Mucopolysaccharidosis Type IVA (Morquio A Syndrome). The key objectives are to: 1) optimize the RTB:GALNS construct for...
This $339,300 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports Triangle Biotechnology's development of a nanodroplet-enhanced sonication technology called ChromExtract. The goal is to enable high-quality, high-yield, and consistent chromatin extraction from formalin-fixed, paraffin-embedded (FFPE) tissue samples for downstream chromatin profiling and accessibility analyses. The...
This federal Project Grant award of $277,033 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the CFDA program "Discovery and Applied Research for Technological Innovations to Improve Human Health" supports research to develop novel methods for introducing radiolabeled trifluoromethyl groups ([11C]CF3 and [18F]CF3) into PET tracers. The key objectives are to: 1) Develop a general strategy to transform alkyl halides into corresponding alkyl-[11C]CF3 and...
This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $300,000 to New York University (NYU) to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives are: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing fluorinated coiled-coil hydrogels that change with temperature, and 3) assessing the potential of these materials as...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $275,773 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Dropletpharm Inc., a for-profit company. The grant supports Dropletpharm's development of microfluidic technologies to enable low-cost and distributed manufacturing of radiopharmaceuticals for clinical and research applications. Specifically, the project aims to expand...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $986,651 to Auragent Bioscience LLC (doing business as Brightest Bio) to develop an ultrabright fluorescent reagent called a Plasmonic Fluor (PF). The PF technology is designed to significantly enhance the detection sensitivity of fluorescent Western blot assays, enabling more precise protein concentration measurements and...
This $350,000 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development and optimization of a novel, enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. The objective is to create a rapid, reliable, and cost-effective platform that can accurately sequence proteins, including those with post-translational modifications, through the...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $303,024 to Biocognon LLC to develop an innovative combinatorial nanobody discovery platform for G-protein coupled receptors (GPCRs). The project aims to: Develop a robust assembly system for creating GPCR/nanobody libraries, Build a synthetic nanobody library targeting the ADRB1 and ADRB2 GPCRs and validate therapeutic...