Project Grant R43GM155492
Award Date
8/15/24
Completion Date
2/14/25
Dollars Obligated
$356K
Federal Agency
National Institute of General Medical Sciences
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Mountain View, CA 94043, USA
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), is focused on developing a novel high-throughput, high-content imaging platform for analyzing extracellular vesicles (EVs) at the single-particle level. The $298,999 award to Numentus Technologies Inc. will fund the construction, testing, and application of this platform to detect and characterize EV subpopulations, including...
The National Institute of General Medical Sciences (NIGMS) awarded a $218,622 Project Grant to Vitan-Biotech LLC on September 22, 2023 under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund the development of an integrated pipeline to rapidly discover and characterize selective, high-affinity nanobodies against defined G protein-coupled receptors (GPCRs) that are important for neurological disorders like schizophrenia, pain, Parkinson's, Alzheimer's, and...
This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of extracellular vesicles (EVs) as therapeutic carriers. The $622,000 award, effective August 1, 2024 through July 31, 2027, will enable researchers at The Washington University in St. Louis to engineer endothelial cell-derived EVs to efficiently...
This $847,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research by The Medical College of Wisconsin, Inc. (MCW) to determine whether extracellular vesicle-enclosed Y5-RNA mediates the age-dependent impairment of angiogenesis (the formation of new blood vessels). The research aims to examine if decreases in Y5-RNA in endothelial cell-derived extracellular vesicles contribute to endothelial cell senescence and impaired angiogenesis in aged...
The National Institute of General Medical Sciences (NIGMS) awarded a $3,895,802 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small disadvantaged business. The grant, awarded on August 1, 2024, supports the development of a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities for characterizing charge variants in biologics. The proposed technology...
The National Institute of General Medical Sciences (NIGMS) awarded a $905,853 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Molecular Instruments, Inc. to develop innovative signal amplification technologies for automated, ultrasensitive, and multiplex imaging of RNA and proteins in biological samples. The 2-year project aims to engineer novel chromogenic and fluorescent signal amplification cascades based on hybridization chain reaction (HCR) to enable 4-plex RNA in...
This $500,000 National Science Foundation project grant supports research to advance the biom anufacturing of extracellular vesicles through the integration of human induced pluripotent stem cell technology, genome engineering, and membrane nanofabrication. The primary recipient is Syracuse University, with Rochester Institute of Technology serving as a sub-awardee. Under the Biological Sciences program (CFDA 47.074), the grantees will work to generate a stable human iPSC line with enhanced EV...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 Biomedical Research and Research Training provides $350,000 to Fluidispec LLC to develop a new microfluidic/nanofluidic sample preparation platform. The goal is to improve single-cell and low-input proteomics analysis by enabling efficient extraction of proteins from cells, removal of contaminants, and improved protein denaturation. This platform is expected to enhance...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,816 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Narwhal Bio, Inc. in San Diego, CA. The grant supports the development of a prototype instrument, software, and consumable for non-invasive live-cell identification, tagging, and downstream characterization. This novel platform aims to enable researchers to study clinically relevant cell-cell interactions that drive diseases like...
This $306,509 federal Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Captis Diagnostics Inc. aims to develop a technology platform for rapid magnetic isolation of neuronal extracellular vesicles (EVs) from blood plasma samples. The goal is to enable the detection of biomarkers for neurological diseases such as Alzheimer's, Parkinson's, and traumatic brain injury through a minimally invasive liquid biopsy approach. Key activities include developing...