Project Grant R43GM131535

This $315,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development of chemoenzymatic methods and reagents to produce affordable glycosphingolipids (GSLs), a class of lipids with complex carbohydrate structures that are ubiquitous in cell membranes. The key objectives are to: 1) expand the inventory of commercially available recombinant glycosyltransferase enzymes...

Professor Liming Zhang of the University of California, Santa Barbara will develop new methods for the automated synthesis of glycans under a three-year, $575,000 Project Grant from the National Science Foundation Division of Chemistry. The grant falls under the NSF's Mathematical and Physical Sciences program (CFDA 47.049). Specifically, Professor Zhang will further develop and validate the Directing-Group-on-Leaving-Group strategy for stereoselective glycosylation reactions appropriate for...

The National Institute of General Medical Sciences (NIGMS) awarded a $413,036 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Arizona State University (ASU) to develop a new single-molecule sequencing method for glycosaminoglycans (GAGs) using fluorophore-labeled lysosomal GAG degradation enzymes. GAGs are a family of complex polysaccharides with diverse biological functions, but their analysis has been challenging due to their size, complexity, and...

The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...

This federal Project Grant award of $390,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a versatile, small molecule-based platform to map the "reader proteins" of critical glycosylation, such as sialylation and core fucosylation. The research program seeks to decipher the protein-carbohydrate interaction code, particularly for disease-related interactions, to lay the...

The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...

The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $325,500 project grant to Trustees of Boston College to support the chemical synthesis of biologically significant polysaccharides via living polymerization. The project aims to develop a platform for the scalable synthesis of various polysaccharides, including linear and branched glucan, mannan, arabinan, arabinomannan, poly-N-acetylglucosamine,...

The National Science Foundation Division of Chemistry awarded a $374,888 Project Grant to Texas A&M University-Corpus Christi to support research examining the effect of templating agents on the size, shape, and chiral recognition of bifurcated amino acid-based amphiphilic molecular assemblies. The goal is to understand factors controlling self-assembly and interactions with biologically relevant molecules of these novel branched surfactant systems. A collaboration between Texas A&M...

The National Institute of General Medical Sciences (NIGMS) has awarded a 5-year, $471,019 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Georgia Tech Research Corporation (Georgia Tech Research Corp) to characterize extracellular glycoproteins and study their functions. The project aims to develop innovative mass spectrometry-based methods to comprehensively analyze glycoproteins on cell surfaces and in the secretome, as well as investigate the...

This Project Grant award, valued at $417,243 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the synthesis of homogeneous proteoglycan-like glycopeptide and glycoprotein libraries for microarray studies. The goal is to develop innovative chemical, chemoenzymatic, and chemoselective ligation strategies to produce well-defined proteoglycan structures, which will then be incorporated into...