Project Grant R01GM160917
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- The University of Southern California received a $342,342 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) for their project titled "CHEMISTRY-ENABLED GLYCOSCIENCE." The project aims to develop and apply chemistry-enabled approaches to address unresolved questions in the field of glycoscience, which studies the role of glycans (complex carbohydrates) in biological processes and...
- This Project Grant award, valued at $417,243 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the synthesis of homogeneous proteoglycan-like glycopeptide and glycoprotein libraries for microarray studies. The goal is to develop innovative chemical, chemoenzymatic, and chemoselective ligation strategies to produce well-defined proteoglycan structures, which will then be incorporated into...
- The National Institute of General Medical Sciences (NIGMS) awarded a $434,385 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maine System, University of Maine Division. The grant, awarded on September 15, 2024, supports the development of a customizable 3D matrix to investigate the role of glycans in human health and disease. The research aims to enable the identification and characterization of glycan-protein interactions in a...
- This $575,000 project grant awarded by the National Science Foundation's (NSF) Division of Chemistry (CFDA 47.049 - Mathematical and Physical Sciences) will support a research effort led by Professor George O'Doherty at Northeastern University to develop novel synthetic methods for the asymmetric synthesis of oligosaccharide structures. The project aims to enable the efficient, de novo construction of both natural and unnatural oligosaccharide motifs, which have important applications in biology...
- This federal Project Grant award of $620,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports a research project at Boston College focused on "Catalytic Radical Processes for Stereoselective Chemical Synthesis." The research aims to establish metalloradical catalysis as a framework for controlling the reactivity and stereoselectivity of homolytic radical reactions in organic synthesis. The...
- This federal Project Grant award of $390,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) aims to develop a versatile, small molecule-based platform to map the "reader proteins" of critical glycosylation, such as sialylation and core fucosylation. The research program seeks to decipher the protein-carbohydrate interaction code, particularly for disease-related interactions, to lay the...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,710 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Z Biotech, LLC to develop a glycan binding protein (GBP)-based glycosylation analysis system. The project aims to address limitations in current glycan structure analysis methods by: Collecting a large glycan array dataset to improve prediction of glycan binding affinities; Expanding coverage of glycan epitopes by supplementing with additional...
- This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $454,478 to The Johns Hopkins University for a project titled "Perfecting Tools to Define the Glycan-Protein Interactome". The project aims to develop advanced chemical probes and computational techniques to map the interactions between glycans (sugar structures) and proteins, which play critical roles in regulating cell physiology and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $382,500 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Texas A&M Engineering Experiment Station (Tees) for the project "Role of Membrane Dynamics in Cell Surface Glycan Recognition" from January 1, 2025 to December 31, 2029. The goal of this project is to investigate how the spatial organization of glycan ligands on cell membranes influences glycobiology processes, and to develop...
The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $325,500 project grant to Trustees of Boston College to support the chemical synthesis of biologically significant polysaccharides via living polymerization. The project aims to develop a platform for the scalable synthesis of various polysaccharides, including linear and branched glucan, mannan, arabinan, arabinomannan, poly-N-acetylglucosamine, and polyglucuronic acid, with precise control over molecular weight, dispersity, chain-end groups, and chain architectures. This research, with a performance period from September 1, 2025, to August 31, 2026, seeks to address the challenges in accessing chemically defined complex glycans and establish a better understanding of structure-function relationships of polysaccharides for various biomedical applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $325.5k | 8/26/25 |