Project Grant R35GM158263
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This Project Grant award of $384,896.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop novel peptide-based biomaterials that can directly modulate cell and tissue responses. The goal is to create advanced biomodulatory materials, such as self-adjuvanting vaccines, anti-inflammatory therapeutics, cell-targeted cancer therapies, and bone regenerative products, to address challenges in...
- This federal Project Grant award of $146,816.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to develop general strategies for the biocatalytic synthesis of N-N and C-N heterobiaryl atropisomers, a class of medicinally relevant chiral compounds that are difficult to obtain through other methods. The research outlined will employ bioinformatic techniques to...
- The federal Project Grant award of $186,354 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is being used to conduct research on the roles of protein glycosylation in prokaryotes. The project aims to perform quantitative glycoproteomic analyses of the opportunistic bacterial pathogen Pseudomonas aeruginosa during different stages of biofilm formation and in response to antibiotics. Additionally, the...
- This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $454,478 to The Johns Hopkins University for a project titled "Perfecting Tools to Define the Glycan-Protein Interactome". The project aims to develop advanced chemical probes and computational techniques to map the interactions between glycans (sugar structures) and proteins, which play critical roles in regulating cell physiology and...
- The National Institute of General Medical Sciences (NIGMS), through its Biomedical Research and Research Training program (CFDA 93.859), awarded a $325,500 project grant to Trustees of Boston College to support the chemical synthesis of biologically significant polysaccharides via living polymerization. The project aims to develop a platform for the scalable synthesis of various polysaccharides, including linear and branched glucan, mannan, arabinan, arabinomannan, poly-N-acetylglucosamine,...
- This federal Project Grant award of $123,737.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance drug discovery for protein domains containing intrinsically disordered regions. The award was granted to the Regents of the University of Michigan, a prominent U.S. state government-owned educational institution, with a performance period from October 1, 2024 to April 30, 2025. The NIGMS...
- This federal Project Grant award for $439,992.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of (a) efficient molecularly imprinted nanoparticle (MINP)-based artificial enzymes for selective hydrolysis of glycans, esters, and amides, and (b) MINP-MINP conjugates for binding complex biomolecules such as glycoproteins and post-translationally modified proteins. The grant,...
- This $306,782 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the continued development and validation of a panel of six sialoglycan-recognizing probes (SGRPs) by Z Biotech, LLC. The project aims to optimize these specialized molecular tools, which leverage naturally evolved microbial sialoglycan-binding proteins, for use in common laboratory techniques like ELISA, Western...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new reagents and methods for synthesizing oligophosphate constructs - phosphorylated biomolecules that play essential roles in human physiology and health. The $444,262 award, effective June 1, 2025 through March 31, 2030, will enable the Massachusetts Institute of Technology (MIT) to: Develop...
This Project Grant award, valued at $417,243 and funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the synthesis of homogeneous proteoglycan-like glycopeptide and glycoprotein libraries for microarray studies. The goal is to develop innovative chemical, chemoenzymatic, and chemoselective ligation strategies to produce well-defined proteoglycan structures, which will then be incorporated into a proteoglycan microarray. This microarray will be used to screen the binding of various proteins, including growth factors, cell adhesion molecules, amyloid beta, and tau, in order to better understand the key structural features of proteoglycans that influence their biological functions. The project is being conducted by Michigan State University and has an award period from August 10, 2025 to July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $417.2k | 8/5/25 |