Project Grant R43EY038518
- The National Eye Institute awarded Oregon Health & Science University $498,180 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop and apply novel optical coherence tomography (OCT) methods for detecting and monitoring photoreceptor changes associated with age-related macular degeneration. The project runs through August 31, 2030, with performance based in Portland, Oregon. Aim 1 investigates cone photoreceptor function impairments in AMD through advancement of...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $733,137 to the University of California, Los Angeles on September 15, 2025, under the Vision Research program (CFDA 93.867) to explore how genetic variation influences disease progression and therapeutic response in age-related macular degeneration. The project integrates advanced optical coherence tomography imaging with machine learning and artificial intelligence to classify...
- The National Eye Institute awarded The Leland Stanford Junior University $666,976 on August 1, 2026, under the Vision Research program (CFDA 93.867) to map age-related macular degeneration (AMD) using precision proteomics and molecular aging analysis. The recipient will deploy the TEMPO (Tracing Expression of Multiple Protein Origins) platform to profile protein biomarkers and identify cellular drivers of AMD in living patients using human liquid biopsy samples. TEMPO integrates aptamer-based...
- The National Eye Institute awarded Massachusetts Eye and Ear Infirmary $663,406 on April 1, 2026, under the Vision Research program (CFDA 93.867) to elucidate the molecular mechanisms of secondary cone degeneration in models of retinitis pigmentosa. The recipient will develop a novel AAV-based retinoic acid signaling activator and test whether it can improve photopic visual acuity in multiple mouse models of retinitis pigmentosa. The work will also aim to elucidate the molecular and cellular...
- The National Eye Institute awarded Neovascularx, Inc. $305,321 on September 30, 2025, under the Vision Research program (CFDA 93.867) to clinically develop and commercialize topical ophthalmic products for treating neovascular age-related macular degeneration (NAMD). The project focuses on developing a home-based topical treatment alternative to existing monthly or bimonthly intravitreous injections of VEGF inhibitors. Current injectable therapies, while effective, present significant challenges...
- The National Eye Institute awarded Synvivo Inc. $290,400 on September 15, 2026, under the Vision Research program (CFDA 93.867) to develop the first standardized, commercial retinal barrier-on-chip using donor-matched human primary retinal pigment epithelial and choroidal endothelial cells for age-related macular degeneration (AMD) therapeutic testing. Synvivo will design and fabricate a retinal barrier-on-chip in a 3-plex array configuration integrating human choroidal endothelial cells...
- The National Eye Institute awarded Baylor College of Medicine $646,167 on April 1, 2026, for investigations of cellular and molecular mechanisms underlying age-related macular degeneration (AMD) under the Vision Research program (CFDA 93.867). The project applies high-throughput functional genomics approaches to test whether non-coding risk variants in AMD exert their effects through gene expression regulation enriched within specific functional networks in disease-relevant tissues. The work...
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- The National Eye Institute awarded Nanoscope Instruments, Inc., $1,019,678 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop and validate the Multi-Luminance Shape Discrimination Test, a device that measures functional vision in patients with moderate to severe vision loss. The recipient will evaluate the retest variability and performance of the Multi-Luminance Shape Discrimination Test in patients with geographic atrophy, wet age-related macular degeneration,...
The National Eye Institute awarded Perzeption Inc. $305,406 on September 1, 2026, under the Vision Research program (CFDA 93.867) to develop and evaluate an efficient photostress recovery assessment method for age-related macular degeneration. The project addresses the need for sensitive functional biomarkers to detect early-stage AMD and measure disease progression or treatment response. Perzeption will develop a novel, personalized, adaptive testing method to assess photostress recovery in cone photoreceptors in under five minutes, then evaluate its sensitivity across different stages of AMD and compare it with existing clinical instruments. Current photostress recovery testing, which typically examines rod photoreceptors, requires specialist equipment, controlled testing spaces, technician supervision, and up to twenty minutes per eye. Cone photoreceptor testing offers faster recovery times and thus the potential for abbreviated assessment protocols. The work is performed in Irvine, California, with a period of performance from September 1, 2026, through August 31, 2027. This is a Project Grant, the assistance type used by NEI for competitive research proposals selected through peer review.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $305.4k | 9/2/26 |