Project Grant R43DA066396
- The National Institute on Drug Abuse awarded Praeventix LLC $355,190 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct in vivo characterization of 5-HT7 modulators in rat models of opioid use disorder. The work evaluates the impact of the lead compound PRA078, a novel 5-HT7 antagonist, on dopamine pathways and cognitive flexibility in animal models of opioid dependence. The research addresses therapeutic gaps in opioid use disorder treatment, where...
- The National Institute on Drug Abuse awarded Yale University $659,834 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate cannabinoid receptor type 1 (CB1R) availability in individuals with opioid use disorder. The study uses [11C]OMAR PET imaging to assess CB1R availability in 55 early abstinent individuals with opioid use disorder following inpatient buprenorphine stabilization and 55 matched healthy controls (total N=110). Individuals with...
- The National Institute on Drug Abuse awarded the University of Southern California $108,000 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the molecular mechanisms of a kappa opioid receptor selective negative allosteric modulator as a potential therapeutic approach to opioid addiction and overdose. The research seeks to elucidate the structural and functional basis of kappa opioid receptor modulation through negative allosteric...
- The National Institute on Drug Abuse awarded The McLean Hospital Corporation $736,811 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a longitudinal cohort study of opioid use disorder. The project characterizes the long-term course of opioid use disorder through remote follow-up of 550 adults with opioid use disorder recruited from sites across the United States. The study employs monthly patient-reported outcomes and annual...
- The National Institute on Drug Abuse awarded Transchromix LLC $399,994 on July 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop a therapeutic strategy targeting non-fatal opioid overdose-induced hypoxia-related brain injuries. The recipient will develop MS1262, a novel G9A inhibitor previously characterized as effective in Alzheimer's disease models, as a treatment for complications arising from respiratory suppression and hypoxia following non-fatal opioid...
- The National Institute on Drug Abuse (NIDA), within the Department of Health and Human Services, awarded Massachusetts General Hospital $451,670 on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support final preclinical evaluation of a positron emission tomography neuroimaging probe for measuring mu opioid receptor density and occupancy in the human brain. The award funds development and validation of 18F-fluorocarfentanil (18F-FCFN) derivatives as safe,...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $466,363 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize allosteric crosstalk among opioid and endogenous neuromodulator receptors. The project uses cryo-electron microscopy to determine high-resolution structures of the mu-opioid receptor in active and inactive states bound to cannabinoids and neuropeptides including oxytocin. The work advances time-resolved cryo-EM...
- The National Institute on Drug Abuse awarded Virginia Commonwealth University a $3.444 million cooperative agreement on September 15, 2025, to develop preliminary safety and early efficacy data for VVZ-2471, a novel 5-HT2A and mGluR5 antagonist candidate for opioid use disorder under the Drug Use and Addiction Research Programs (CFDA 93.279). VVZ-2471, developed by Vivozon Inc in collaboration with VCU, demonstrated in preclinical studies the ability to reduce morphine self-administration and...
- The National Institute on Drug Abuse awarded Cessation Therapeutics, Inc. a Cooperative Agreement of $7.315 million on September 15, 2025, to advance clinical development of CSX-1004, a human IgG1 monoclonal antibody designed to provide prophylaxis against fentanyl and fentanyl analog overdose. The award funds Phase 2 proof-of-concept fentanyl challenge studies in healthy subjects and subjects with opioid use disorder, with the ultimate target product profile being a fixed-dose subcutaneous...
- The National Institute on Drug Abuse awarded Brown University $480,276 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 1, 2026, to co-develop a brief intervention with young adults aged 18–25 who have opioid use disorder and prematurely terminated treatment, aimed at reducing overdose risk and reengaging participants in evidence-based medication for opioid use disorder (MOUD). The K99/R00 award funds two phases of research. During the K99 phase, the project will...
The National Institute on Drug Abuse, part of the Department of Health and Human Services, awarded Longieva Therapeutics, Inc. $399,989 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct Phase I SBIR research evaluating the efficacy of a novel cannabinoid receptor 2 agonist against opioid use disorder. Longieva is developing 36040, a cAMP-biased CB2R agonist designed to mitigate opioid dependence by reducing dopaminergic neuron excitability and blunting reward-reinforcement signaling in the nucleus accumbens. The compound distinguishes itself from prior CB2R agonists through minimal beta-arrestin activity, a signaling profile intended to avoid receptor desensitization and tolerance. Preclinical studies have demonstrated robust efficacy in models of methamphetamine addiction and reduced oxycodone dependence when co-administered, along with favorable drug-like properties and tolerability in animal studies. 36040 is currently in IND-enabling studies for methamphetamine use disorder; this award funds evaluation against opioid use disorder as a distinct indication. The research addresses the public health crisis of opioid overdose deaths, which numbered approximately 48,422 in 2024 from synthetic opioids, particularly fentanyl. Existing treatments such as buprenorphine and methadone face limitations from misuse concerns, diversion risk, and regulatory barriers. The work is performed in Menlo Park, California, with a period of performance ending July 31, 2027. The development occurred in collaboration with NIDA and the NIH Blueprint Neurotherapeutics Program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/17/26 | ||
| Not listed | $400.0k | 8/10/26 |