Project Grant R43AT013554
- The National Center for Complementary and Integrative Health (NCCIH), part of the U.S. Department of Health and Human Services, awarded a $306,872 Project Grant under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to Evoquant LLC. The funding supports the development of the "BioPredictor" platform, an innovative artificial intelligence and multi-omics system designed to enhance natural product drug discovery and target selection. The project...
- The National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), awarded a $1,262,764 project grant to the Sloan-Kettering Institute for Cancer Research. The grant is intended to support research on the use of isoquercetin, a flavonoid compound, as an inhibitor of protein disulfide isomerase (PDI) to develop an antithrombotic agent for cancer patients at high risk of venous thromboembolism. The...
- This $607,561 federal Project Grant award from the USDA National Institute of Food and Agriculture (NIFA) under the Agriculture and Food Research Initiative (AFRI) program will support a 3-year study to investigate the effects of ginger supplementation on neuropathic pain, gut function, and related biomarkers in individuals with sciatica. The primary objective is to evaluate how 2 months of ginger intake impacts gut microbiota composition, fecal metabolites, and markers of intestinal...
- This $306,865 federal project grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), aims to use scalable ultrasonic nano-emulsification to improve the pharmacokinetic properties of the natural product curcumin. The goal is to enable the effective use of curcumin, a therapeutically promising but poorly water-soluble natural compound, in disease treatment. The project...
- The federal Project Grant award titled "Neural Circuitry of Motion-Induced Nausea" was provided by the National Center for Complementary and Integrative Health (NCCIH) under CFDA Program 93.213, "Research and Training in Complementary and Integrative Health." The $250,000 grant, awarded on September 23, 2025, supports research conducted by Northwestern University to study the neurons and neural circuits responsible for motion-induced nausea. The research aims to establish the...
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 - Research and Training in Complementary and Integrative Health provides $451,000.00 in funding to The Trustees of Princeton University from September 2024 to August 2026. The objective is to characterize the secondary metabolomes of three Corynebacterial strains, including uncovering the small molecule products they use to compete with other microbes and interact with host cells....
- This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the federal Research and Training in Complementary and Integrative Health program (CFDA 93.213), provides $306,793 to Vivoverse, LLC, a woman-owned small business in Austin, Texas, to develop an automated high-throughput screening platform using the C. elegans model organism. The project aims to create imaging-based assays to assess the effects of natural products, including plant extracts...
- This $222,412 Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) will fund a 2-year research project at the University of South Florida to study the natural products derived from archived coral specimens held in natural history museum collections. The project aims to leverage recent advancements in analytical instrumentation and bioinformatic platforms to...
- The National Center for Complementary and Integrative Health (NCCIH) awarded a $466,125 Project Grant under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) to Weill Medical College of Cornell University. The project, titled "PUFA Partitioning into Condensates as a New Mechanism for Gene Regulation," aims to explore a new explanation for why specific polyunsaturated fatty acids (PUFAs) regulate PPARG-mediated transcription initiation more than...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $308,925 to Chemia Biosciences, Inc. to develop computational technologies for discovering novel fungal natural products with potential antimicrobial and therapeutic applications. The primary goal is to create software that can predict the molecular structures of natural products encoded in fungal genomes, leveraging high-throughput...
This federal Project Grant award, totaling $416,134, was provided by the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213). The grant supports the development of a botanical drug product called ZINDOL, which is based on ginger, for the treatment of chemotherapy-induced nausea and vomiting (CINV). The project aims to develop and manufacture a highly purified and standardized ginger-based active pharmaceutical ingredient (API) as well as a formulated drug product in gelatin capsules. Key activities include product characterization, stability studies, in vitro nausea assays, scale-up manufacturing, IND-enabling toxicology and pharmacology studies, and clinical trials in adults undergoing chemotherapy. The award period runs from September 1, 2025 to August 31, 2026 and is being conducted by the minority-owned biotechnology company Aphios Corp located in North Reading, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $416.1k | 8/28/25 |