This Project Grant award for $295,780 from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) supports the development of a high-throughput in vivo screening platform for identifying novel probiotic and postbiotic bacterial strains. The grantee, Nemalife Inc., a for-profit biotechnology company, will leverage the nematode Caenorhabditis elegans as a model organism to rapidly test and...
This $1,044,855 Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund Nemalife Inc. to deliver high-throughput testing of anti-aging and FDA-approved drugs in genetically diverse invertebrate Alzheimer's disease models. Under the Aging Research program (CFDA 93.866), the awardee will screen 300 anti-aging compounds and 200 FDA drugs to identify candidates that improve neuronal aging and protect against protein misfolding diseases...
This $644,864 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports preclinical studies by Ridgeline Therapeutics LLC, a Houston-based biotech company, to evaluate the efficacy of their lead compound RT-002 in preventing and reversing disuse-induced muscle atrophy in aging rat models. Specifically, the project aims to determine if RT-002 treatment can mitigate the loss of muscle mass and strength during muscle disuse, as well as improve the rate...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $485,375.00 in funding to the University of Washington to develop a three-dimensional engineered muscle tissue (3D-EMT) model to study the metabolic response to muscle contraction in the context of aging. The project aims to examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction observed in aged muscle, as well as characterize the effects of...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $387,006.00 to Emory University to conduct research on how indoles from commensal gut bacteria can promote mobility and muscle function in aging. The research aims to elucidate the mechanisms by which indoles, acting through the aryl hydrocarbon receptor, can limit age-related loss of muscle proteins and mitochondrial function to maintain mobility in aged animals. The grant...
This $141,354 federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA 93.213 (Research and Training in Complementary and Integrative Health) will support research into identifying novel bioactive natural products from estuarine sediment microbial communities. The research aims to investigate the potential of these microbial communities as sources of new compounds with pharmaceutical applications, such as those targeting the GRP78 protein...
The National Institute on Aging (NIA) awarded Neucyte Inc., a minority-owned small business, a $500,000 Project Grant under the Aging Research program (CFDA 93.866) to develop a nanoluciferase-based microphysiological systems platform for high-throughput screening of Alzheimer's disease (AD) and AD-related dementia (ADRD) therapeutics. The platform will utilize induced pluripotent stem cell-derived "mini-brain" assembloids to create scalable, reproducible 3D brain models that better...
This $308,925 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) aims to develop advanced computational technologies for discovering novel fungal natural products with potential biomedical applications, particularly in the realm of antibiotics and therapeutics. The recipient, Chemia Biosciences, Inc., a self-certified small disadvantaged business, is leveraging high-throughput mass...
This $1,001,704 Cooperative Agreement award from the National Institute on Aging (NIA, CFDA 93.866 Aging Research) will support a multi-year project to validate methods for analyzing NAD and its metabolites in human clinical studies. The project aims to: Develop and standardize analytical methods for measuring NAD, NADH, NADP, and NADPH in blood-derived samples, including through liquid chromatography-mass spectrometry, biochemical assays, and nuclear magnetic resonance. Conduct a clinical trial...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the molecular mechanisms responsible for sarcopenia, the loss of muscle mass and function associated with aging. The $576,893 award to the University of Texas Medical Branch at Galveston will test the hypothesis that post-translational modifications of the myosin protein and its chaperone UNC-45 contribute to the diminished muscle function observed in elderly populations....