This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), provides $631,382 to the Sloan-Kettering Institute for Cancer Research to conduct research on isoquercetin as a potential anticoagulant treatment for cancer-associated thrombosis. The key objectives are to: 1) Determine the optimal dosing of isoquercetin based on its ability to inhibit protein disulfide isomerase (PDI), a key mediator of thrombosis, in patients with ovarian cancer; and 2) Identify which hypercoagulable phenotypes in cancer patients are most responsive to PDI inhibition by isoquercetin, in order to enable a more targeted, safe, and effective approach to thromboprophylaxis in cancer care. The award period is from April 15, 2025 to January 31, 2030, and the research will be conducted at the Sloan-Kettering Institute facility in New York.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $631.4k | 4/10/25 |