Project Grant R43AT011168

This Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $474,861 to North Carolina State University under the Engineering program (CFDA 47.041) from January 15, 2023 to December 31, 2027. The award will fund research to develop strategies for improving the ability of genetically engineered probiotic yeast to reside long-term in the gut, with the goal of enabling in situ biomanufacturing of therapeutic agents to...

This $350,000 project grant awarded by the National Science Foundation (NSF) Engineering program (CFDA 47.041) aims to develop a yeast strain with a robust protein secretion system that is tolerant to extreme pH and temperature levels. The primary objectives are to engineer the secretory pathway of the yeast Kluyveromyces marxianus using gene editing tools such as CRISPR, identify critical genes influencing protein production and secretion, and develop effective CRISPR libraries and selection...

Berkeley Fermentation Science Inc., doing business as Berkeley Brewing Science, was awarded a $100,000 Project Grant from the United States Department of Agriculture National Institute of Food and Agriculture under the Small Business Innovation Research (SBIR) Program/Small Business Technology Transfer (STTR) Program. The grant funds research to engineer Saccharomyces cerevisiae yeast for increased biotransformation and production of tropical flavors from agricultural products. The SBIR/STTR...

The National Science Foundation awarded a $422,834 Project Grant to the University of California Irvine under the Engineering federal grant program (CFDA 47.041) for research titled "Collaborative Research: Data-Driven Engineering of the Thermotolerant Yeast Kluyveromyces Marxianus." The three-year project period runs from October 1, 2022 to September 30, 2025. The award will support applying machine learning and deep learning techniques to metabolic engineering of yeast for...

The National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded a $400,000 Project Grant to the Regents of the University of California at Riverside under the Engineering (47.041) federal grant program. The three-year award will support collaborative research using machine learning and synthetic biology approaches to engineer the thermotolerant yeast Kluyveromyces marxianus to maximize production of malonyl-coA, a key precursor to polyketides....

This Project Grant award from the National Science Foundation's (NSF) Engineering program (CFDA 47.041) provides $545,000 to Trustees of Tufts College (doing business as Trustee of Tufts College) to explore optimizing the productivity of the food-safe yeast Pichia pastoris. The project will focus on understanding how this yeast allocates resources for protein synthesis, with the goal of maximizing productivity for food, biomedical, and scientific applications. Key activities include evaluating...

The National Science Foundation (NSF) Engineering program (CFDA 47.041) awarded a $349,999 Project Grant to the University of California Irvine (UC Irvine) to conduct collaborative research on engineering the yeast Kluyveromyces marxianus for enhanced protein secretion. The key objectives are to develop a yeast strain with a robust protein secretion system that is tolerant to extreme pH and temperature levels, and to improve STEM education for underrepresented minorities and non-traditional...

This Project Grant award from the National Science Foundation (NSF) under the Biological Sciences program (CFDA 47.074) provides $369,297 to San Francisco State University (SFSU) to develop a synthetic transhydrogenation module to enhance the production of valuable chemicals using engineered organisms. The key objectives are to: Elucidate the structural mechanisms underlying the autoregulation of the GltAB-GudB enzyme complex in Bacillus subtilis, which regulates glutamate metabolism and impacts...

This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) provides $460,166.00 to Ohio University to engineer Lactococcus lactis bacteria as a platform for targeted delivery of bioactive lasso peptides. The goal is to leverage synthetic biology techniques to rewire the metabolic pathways of L. lactis, enabling the production and controlled release of natural products like the anti-diabetic/weight-control compound...

This federal Project Grant award from the U.S. Department of Agriculture's National Institute of Food and Agriculture (USDA NIFA), under the Small Business Innovation Research (SBIR) Program (CFDA 10.212), provides $650,000 to Sasya Inc. to develop a tailored probiotic strain capable of directly producing nutrients in the gastrointestinal tract of broiler chickens. The key objectives of this 2-year project are to genetically engineer probiotic bacteria with biosynthetic pathways for producing...