This Project Grant from the National Science Foundation Division of Chemical, Bioengineering, Environmental, and Transport Systems provides $474,861 to North Carolina State University under the Engineering program (CFDA 47.041) from January 15, 2023 to December 31, 2027.
The award will fund research to develop strategies for improving the ability of genetically engineered probiotic yeast to reside long-term in the gut, with the goal of enabling in situ biomanufacturing of therapeutic agents to treat gastrointestinal diseases. The university will engineer yeast that can attach to and metabolize mucus in the intestines, and will develop new courses to train students in microbial engineering and evolution. High school students will participate in labs on evolving probiotics, while undergraduates will take a new course on prospecting genes for biotechnology applications. The work aims to advance gut drug delivery and enhance STEM education for underrepresented groups in North Carolina.
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