This $679,424 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports preclinical studies to evaluate the efficacy of a novel nanoligomer treatment for reducing neuroinflammation and protecting against cognitive decline in mouse models of brain aging and Alzheimer's disease. The research aims to determine the ideal application of the NF-kB/NLRP3-targeted nanoligomer treatment, whether for prevention during aging or treatment of pathology, and to...
This $243,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to address critical knowledge gaps in the care of older adults with inflammatory bowel disease (IBD). The key objectives are to: (1) develop and validate a model to predict which older adults with IBD will require surgery, (2) derive a preoperative model to predict risk of major postoperative complications, including measures of sarcopenia, cognition, and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of the CD38 enzyme and CD8 tissue-resident memory (TRM) cells in the development of chronic lung fibrosis following viral pneumonia, including COVID-19. The $639,740 award, effective December 15, 2024, aims to explore the hypothesis that targeting CD38 could mitigate age-associated chronic lung sequelae by dampening aberrant CD8 TRM accumulation. The study will...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,189,692 in funding to Bloom Science, Inc. to develop a neuroprotective engineered bacteria for the treatment of Alzheimer's disease. The project aims to leverage the probiotic bacterium Akkermansia muciniphila and engineer it to produce anti-inflammatory compounds such as butyrate, beta-hydroxybutyrate, and tauroursodeoxycholic acid (TUDCA) to reduce neuroinflammation and slow disease...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $252,152 to the Benaroya Research Institute at Virginia Mason to characterize T cells specific for the autoantigen integrin αvβ6 in patients with ulcerative colitis. The award will fund research to adapt the Activation Induced Marker (AIM) assay to study T cell-B cell interactions that lead to autoantibody...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $460,625 to the University of Massachusetts Medical School to conduct research on the role of platelets and the MLKL protein in the release of S100 proteins during influenza infection and aging. The key objectives are to: 1) Determine how influenza and aging affect MLKL-mediated platelet content release and necroptosis, and 2) Assess the contribution of aging to MLKL activation and...
This $1,010,081 federal Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports a multi-year research project by Emory University focused on identifying potential "goldilocks zone" immune modulatory therapies for Alzheimer's disease. The overarching goal is to systematically evaluate the liabilities and benefits of different immune system manipulations in preclinical models of amyloid pathology, with the aim of finding interventions that...
This federal Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), aims to develop an effective targeted delivery system for the bioactive curcuminoids curcumin and bisdemethoxycurcumin to treat Alzheimer's disease and other neuroinflammatory disorders. The $1,006,428 award, spanning September 2024 to August 2025, will support the optimization of folate-functionalized exosomal formulations for trans-spinal delivery of these curcuminoids to...
This $184,572 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to characterize the transmural nature of ulcerative colitis (UC) and its impact on disease outcomes. The University of Chicago is the prime recipient. The research aims to: 1) Determine predictors of transmural structural alterations (TMA) to the bowel wall in UC patients;...
This Project Grant award, with a total funding amount of $431,750, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award is for the development and evaluation of a novel immuno-gene therapy approach using a single-chain fragment variable (scFv) derived from an anti-tau oligomeric complex 1 (TOC1) antibody. The key objectives are to: 1) generate and validate the TOC1-scFv-HaloTag-Proteasome Degradation Signal (PDS)...