Project Grant R43AG060868

This Project Grant award, with Federal Grant ID R01MH137445, is funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242). The goal of this $770,654 project, running from June 1, 2025 to May 31, 2030, is to establish the efficacy and mechanisms of exercise-enhanced fear extinction retrieval and generalization in individuals with post-traumatic stress disorder (PTSD). The project will compare the impact of different exercise intensities...

This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is for the development of a lightweight, cost-effective telerehabilitation device. The device will provide motorized exercise and blood flow restriction capabilities to enhance the effectiveness of low-load exercises for patients recovering from lower limb orthopedic injuries or...

This $556,160 Project Grant awarded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846) aims to examine the efficacy of a rehabilitation approach called Rehabilitation with Exercise and Psychological Support (REPS) for patients who have undergone ACL reconstruction surgery. The REPS intervention integrates standard exercise rehabilitation with psychological support, including clinician training, patient education videos, and techniques like...

This Project Grant award from the Center for Evidence and Practice Improvement, part of the U.S. Department of Health and Human Services, will fund research to examine the feasibility and effectiveness of a remote therapeutic monitoring (RTM) mobile health solution designed to enhance clinical outcomes for patients receiving physical therapy for musculoskeletal pain. The $256,422 award, to be completed by July 2026, will be used by The Johns Hopkins University to conduct a phased research...

This $625,835 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to optimize aerobic fitness and functional response to exercise in older adults. The grant aims to test the efficacy of a combined high-intensity interval training (HIIT) and high-intensity resistance training (HIRT) approach to improve peak oxygen uptake (VO2peak) and physical function in patients eligible for cardiac rehabilitation, compared to standard...

The National Institute of Mental Health (NIMH) awarded a $450,488 project grant under the Mental Health Research Grants program (CFDA 93.242) to the University of Wisconsin - Madison to characterize the acute biobehavioral response to exercise among individuals with restrictive eating disorders (ED). The 2-year project aims to 1) evaluate variability in reward and threat response to exercise, 2) develop tasks to assess exercise-related reward and threat processes, and 3) test hypotheses that...

This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) is focused on testing the effectiveness and implementation of a home-based exercise intervention for individuals with an implantable cardioverter defibrillator (ICD). The primary goal is to determine if the Exercise-ICD (E-ICD) intervention can increase physical activity and improve related health outcomes in this patient population. The $728,781 award to the...

This federal Project Grant award from the National Institutes of Health (NIH) Office of the Director's Trans-NIH Research Support program (CFDA 93.310) provides $308,799 to The Leland Stanford Junior University to conduct a comprehensive multi-omic study mapping exercise-induced signaling pathways and interorgan communication. The research aims to define a catalog of exercise-induced secreted factors ("exerkines") and their receptors across 17 organ systems, using data from the...

This Project Grant award from the National Center for Complementary and Integrative Health (NCCIH), under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), will fund the development and evaluation of a tailored progressive muscle relaxation and walking intervention to reduce fatigue in adults with end-stage kidney disease (ESKD). The $712,508 award will be used by the University of Illinois to conduct an early-phase clinical trial (R34) to assess the...

This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $452,181 to develop and test an 8-week exercise-based frailty intervention called XFIT for lung transplant candidates. The goal is to improve physical function and reduce frailty in this population at high risk for disability and mortality. The award includes sub-grants to Columbia University ($352,181) and the University of Pennsylvania ($100,000) to serve as study...