Project Grant R42AI131823

Federal Project Grant Award Summary Prodigy Biotech, Inc. received a $314,363 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on September 23, 2025, with completion targeted for August 31, 2026. The award funds the development and evaluation of a novel immunoglobulin Y (IGY) therapeutic platform designed to treat alcohol-associated hepatitis (AH) by targeting the fungus...

This National Science Foundation Project Grant of $255,927 awarded to Invvax, Inc. on March 1, 2022 seeks to develop stable prophylactic antibodies through February 2023. Funded through the NSF Engineering Directorate's CFDA 47.041 program, this Small Business Innovation Research Phase I project will engineer mutations to antibody Fc regions to resist degradation and enhance binding to the neonatal Fc receptor for potentially decades-long duration. Specifically, the awardee will combine known...

This Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) provides $379,730 to the University of North Carolina at Chapel Hill to develop a continuous electrochemical sensor for monitoring therapeutic monoclonal antibodies, using the FDA-approved drug bevacizumab as an example. The research aims to overcome challenges in discriminating between therapeutic antibodies and human IgG in biological fluids, and in regenerating the aptamer binding site for...

Federal Project Grant Award Summary Antigen Discovery Inc. (operating as Immport Therapeutics Inc.) received a $300,000 Project Grant award from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 25, 2025, with completion targeted for July 31, 2027. The award supports development of a sensitive and specific serology-based potency test for whole cell pertussis (WP) vaccines to replace the outdated...

Federal Grant Award Summary Immunowork LLC received a $304,993 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 15, 2025, with completion scheduled for August 31, 2026. The company is developing and validating a flow cytometry-based diagnostic assay that detects and quantifies circulating phospholipase A2 receptor (PLA2R)...

Federal Project Grant Award Summary Protabit LLC received $304,602 in Project Grant funding from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The award, effective August 7, 2025, with completion targeted for July 31, 2026, supports the development of high-throughput engineering technologies for bispecific antibodies—therapeutic molecules that combine two different antigen-binding domains. The project...

Federal Grant Award Summary Nano-Beads Protein Innovations, Inc. received a $620,174 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), awarded September 1, 2025, with completion expected by March 31, 2027. The project aims to develop NANO-AB, an innovative nanoscale biomaterial designed to advance monoclonal antibody (MAb) purification...

Federal Project Grant Award Summary Yolo Immune Inc. received a $304,665 Small Business Innovation Research (SBIR) Phase I award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) on October 1, 2025, with completion scheduled for September 30, 2026. The company is developing a novel immunotherapy drug designed to selectively deplete immunoglobulin G4 (IgG4) autoantibodies, a specific antibody subclass implicated in multiple...

This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $415,329 to Northern Illinois University (NIU) to support research on engineering and characterizing pH-dependent antibodies. The research aims to explore methods for controlling antibody-antigen interactions through the introduction of acidic residues at the interface, with the goal of opening new opportunities for using...

Summary Georgia TECH Research Corp received a $725,241 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded February 2, 2026, with completion targeted for January 31, 2031. The award supports research and development of controlled-delivery HIV vaccine candidates utilizing advanced immunological and pharmaceutical technologies. The project integrates five core components: injectable...