Project Grant R41EB038152
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $651,384 to develop a programmable technology platform that will transform antibody-based therapeutics. The goal is to establish a foundation for next-generation protein countermeasures and therapeutics by synergistically merging two synthetic biology...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $413,067 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Colorado State University to develop a new class of electrochemical biosensors that use engineered binding proteins. The goal is to simplify fabrication and improve performance of electrochemical sensors, which have potential for inexpensive, sensitive, and quantitative...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $222,708 Project Grant to The Trustees of Columbia University in the City of New York under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant, which runs from May 1, 2025 to December 31, 2028, will support research to develop self-assembling modular hydrogels that can programmably display glycan ligands to direct immune cell phenotypes. This...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $821,426 Project Grant on January 16, 2025 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the University of Nebraska Medical Center. The grant supports the development of nanostructures that are selectively targeted to bacteria, with a focus on two pathogens of particular concern: Staphylococcus aureus and Acinetobacter baumannii. The...
- This $342,776 federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop advanced data science methods and an automated pipeline for efficient and high-performance monoclonal antibody (mAb) formulation. The goals are to create a self-driving bioformulation laboratory that leverages artificial intelligence, machine...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $385,383 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the California Institute of Technology (Caltech) on December 1, 2024. The project aims to develop an adaptive framework to rapidly synthesize and reconfigure synthetic bacterial viruses (phages) to counter antibiotic resistance. Specifically, the project will optimize an...
- This federal Project Grant award, valued at $231,934.00, was provided by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports the development of a new modular platform technology that mimics lymph nodes to improve the engineering of T cells for cellular immunotherapy. The funded research aims to create biomimetic scaffolds that can...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The National Center for Advancing Translational Sciences (NCATS) awarded a $275,000 Project Grant (CFDA 93.350) to Nectagen Inc. to develop bioprocess-compatible, second-generation nanoclamp affinity resins for the efficient purification of plasma-based therapeutic proteins. The goal is to identify panels of nanoclamps to 5 industrially relevant plasma-based therapeutics, select lead candidates, and optimize the resins for maximum recovery and purity from plasma samples. This project aims to...
- The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $359,995 Project Grant under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program to Clemson University. The funding supports the development and validation of a novel X-ray visualized immunosensor (X-VIS) that can be attached to implanted medical devices to detect and monitor local infection biomarkers. The project aims to fabricate a...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $310,087 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Nano-Beads Protein Innovations, Inc. The grant will fund the development of an innovative nano-biomaterial called "NANO-AB" for rapid, column-free antibody purification. The NANO-AB system leverages advanced polypeptide-based nano-biomaterials charged with protein A (NANOZ) and protein G (NANOG) ligands to provide superior purification performance compared to current approaches using agarose resins or macro-porous membranes. The Phase I objectives include developing the NANOG variant to address limitations of existing agarose bead options for monoclonal antibody (mAb) purification. The project period runs from Sep 1, 2025 to Mar 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/20/25 | ||
| Not listed | $310.1k | 8/15/25 |