Project Grant R41HD104560

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $500,000 to Starlight Cardiovascular, Inc., a for-profit medical device company in San Diego, to finalize the manufacturing processes, produce devices for clinical use, and obtain Investigational Device Exemption (IDE) approval from the FDA to begin a clinical trial for Starlight's innovative ductus arteriosus stent system. This stent is...

This $306,643 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the development of a new extracorporeal membrane oxygenation (ECMO) pump designed to efficiently accommodate the low flow rates needed for pediatric and neonatal patients. The primary aims are to 1) design, develop, and bench test a low-flow ECMO pump capable of operating at 0.05 to 0.5 L/min to minimize hemolysis and other negative...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $812,343 to Boston Medical Center Corporation to conduct a multicenter, simulation-based randomized controlled trial. The objective is to test the efficacy of teleconsultation with pediatric emergency physicians using video to reduce serious safety events, compared to usual care, in the prehospital...

The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $506,500 Project Grant under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) to Endolynx Inc. in Jersey City, NJ. The project aims to develop an Optical Sensor-Enabled Endotracheal Tube (OS-ETT) to reduce the risks and costs associated with esophageal intubation and unintended extubation during the ~30 million intubations performed annually in the...

This Project Grant award from the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a modern Electrical Impedance Tomography (EIT) device for monitoring children in the Intensive Care Unit (ICU). The $299,900 award to Goodlife Inventors LLC will fund efforts to (1) generate initial designs for an advanced lightweight EIT belt and (2) assess the technical feasibility of a miniaturized, easier to use EIT core device. If...

The National Institute of Child Health and Human Development (NICHD) awarded a $295,897 project grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Neocare Innovations, Inc. to develop a clinical decision support tool called PEDI-SYNC. The goal of PEDI-SYNC is to improve oral feeding outcomes for preterm infants in neonatal intensive care units (NICUs) across the United States. The PEDI-SYNC system consists of a portable unit that measures...

This $866,579 Project Grant was awarded by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Children's Hospital of Philadelphia (CHOP). The grant will fund a 5-year randomized trial to determine if an "Optimizing Ventilation (OPTI-VENT) Bundle" training program can improve cardiac arrest outcomes in children by training healthcare providers to follow the 2020 American Heart...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the advanced development and testing of an optical probe to monitor peripheral tissue oxygenation as a marker of systemic hemodynamics in critically ill neonates. The $318,724 award to Pendar Technologies LLC, a small business manufacturer in Massachusetts, aims to improve the company's resonance...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $454,049 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to Drexel University. The grant supports the development of an innovative central venous catheter device that can provide continuous and accurate measurements of cardiac output in critically ill patients. Key technical innovations include: 1) Using a Doppler ultrasound...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is focused on developing an FDA-approved artificial intelligence (AI)-driven total parenteral nutrition (TPN) platform for premature newborns. The key products and services to be delivered through this $291,523 grant, awarded on September 13, 2024, include: Development of a set of standardized TPN units that...