Project Grant R41DE035423
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...
- This $550,296 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop a multimodal imaging diagnostic platform to improve risk assessment of precancerous oral lesions. The key products and services to be delivered under this grant include: Development of machine learning and deep learning models using Fourier transform infrared (FTIR) imaging techniques for risk...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded Rytek Medical Inc. a $220,000 Project Grant on August 1, 2025. The grant supports research to evaluate CT/X-ray imaging-correlated impedance-based metrics for predicting surgical osseointegration and injury prevention in dental implant procedures. The project aims to develop innovative diagnostic technologies, such as an impedance-based...
- The Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $306,633 to Ther-Ai LLC to develop CRANIAMAP, a foundational software module that enhances auto-segmentation and landmarking capabilities for cone beam computed tomography (CBCT) scans. This SBIR Phase I project aims to outperform existing AI-based tools, achieving at least 90% accuracy in segmenting critical...
- This Project Grant award of $441,247.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports the development of a clinically-calibrated accelerated fatigue test for predicting the clinical performance of dental restorative materials. The project aims to create a Medical Device Development Tool (MDDT) in the form of an accelerated fatigue test that can explicitly predict the...
- The $296,171 Project Grant awarded on August 8, 2025 by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to design and evaluate an impedance-based bone assessment technology for characterizing trabecular bone microarchitecture. This technology is intended to address the limitations of current imaging techniques, like cone beam CT, in accurately quantifying bone quality, particularly in the trabecular...
- This federal Project Grant award in the amount of $299,782.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports the development and validation of an MRI-compatible jaw metabolic stressor task to determine the jaw muscle metabolic stress and brain functional characteristics related to jaw pain perception during function. This research aims to create new models for studying...
- This $597,807 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will establish a novel 13C-labeled metabolite library for the study of dental caries. The key objectives are to: Create a 13C-labeled oral bacterial metabolite reference library for Streptococcus mutans and Streptococcus gordonii using SWATH LC-MS, with dual peaks identified and curated to improve rigor...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $298,942 Project Grant to Deltamed LLC on August 20, 2025. The grant funding will support the development of a novel "nanosponge prodrug delivery system" for the small molecule MK2 inhibitors apatinib and MMI-0100. The goal is to improve the circulation half-life and targeted delivery of these compounds to mitigate...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $341,970.00 to Oralmr LLC to test the feasibility of using a specialized pulse sequence and intraoral coil to detect the dentinoenamel junction (DEJ) in teeth at a lower field strength (0.7T) with greater inhomogeneity than conventional MRI systems. The goal is to develop a cost-effective, dental-dedicated MRI system that can be sited within conventional dental practices without major renovations, enabling non-ionizing, early detection of dental diseases. The project has four specific aims: 1) integrate intraoral dental coils into a 0.7T system, 2) implement the MB-SWIFT pulse sequence on a novel spectrometer, 3) explore the system's ability to capture the DEJ, and 4) validate siting requirements for future dental MRI systems. The award period runs from September 4, 2025 to August 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $342.0k | 9/4/25 |