Project Grant R56DE034690
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $422,665 Project Grant to Oregon State University (OSU) to develop an integrated dental plaque bioanalytical platform for point-of-care diagnostics of oral diseases. The project aims to detect and quantify hydrogen peroxide and lactate produced by beneficial and pathogenic oral bacteria, and establish a correlation between oral caries...
- This federal Project Grant award of $163,411 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), supports research to characterize the nutritional niches and interactions between Streptococcus mutans, a primary driver of dental caries, and other commensal oral streptococci species. The research aims to understand how these microcolony biofilm structures form, the interactions between S....
- This Project Grant award, valued at $645,988.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The primary objective is to leverage an eco-systems biology approach and phage-specific computational platform to define the role of bacteriophages in the development of dental caries and the broader oral microbiome. Key activities include collecting caries-free and caries-active plaque samples,...
- This Project Grant award of $470,279 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to study the impact of bacterial oxidative stress responses on the ecology and pathogenicity of oral streptococci. The research project, conducted at the University of Alabama at Birmingham (UAB), will identify and characterize the hypochlorous acid (HOSCN) response mechanisms in oral streptococci, particularly...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $219,132 Project Grant to Virginia Commonwealth University (VCU) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding will support a 2-year project titled "Demystifying DMFT/DMFS: Pragmatic Nationwide Assessment of Dental Caries Outcomes from NHANES." The project aims to develop advanced statistical methods for efficiently assessing dental caries experience using complex nationwide...
- This $322,000 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support secondary data analysis from the CariesAway study to advance the implementation of school-based oral health programs using silver diamine fluoride (SDF). The research aims to explore the longitudinal caries arrest capabilities of school-based SDF applications, estimate surface-level caries risk...
- This federal Project Grant award of $297,711.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to develop and test zinc tetraammine difluoride (ZAF) as a non-invasive, aesthetic, and cost-effective alternative to traditional dental caries management strategies. The objective is to determine the mineral loading efficacy of ZAF agents in human dentin, with the goal of providing ZAF as a...
- The Project Grant award of $205,000.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the relationship between the oral microbiome and adverse outcomes in pediatric hematopoietic cell transplant recipients. The key products and services to be delivered under this award include: Collecting oral samples (supragingival plaque and saliva) and blood samples...
- This $164,255 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, aims to develop innovative methacrylate-based dental materials that can inhibit the formation of microbial biofilms to prevent secondary caries. The key objectives are to: (1) synthesize a new 2-aminoimidazole derivative, H10, and generate a methacrylate-based antimicrobial agent containing covalently conjugated...
- This federal Project Grant award of $234,000.00, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at Oregon Health & Science University (OHSU) to characterize the natural competence ability of the Prevotella melaninogenica bacterial species. The project aims to break the genetic tractability barrier within the Prevotella genus, which has significantly hindered mechanistic...
This $597,807 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will establish a novel 13C-labeled metabolite library for the study of dental caries. The key objectives are to: Create a 13C-labeled oral bacterial metabolite reference library for Streptococcus mutans and Streptococcus gordonii using SWATH LC-MS, with dual peaks identified and curated to improve rigor and reproducibility in oral metabolomics studies. Evaluate the feasibility and optimize the application of the newly generated oral bacterial metabolite reference library in the study of clinical saliva and plaque samples to investigate caries versus health. Develop an integrated workflow using the 13C-labeled oral bacterial metabolite library combined with differential metabolomics, transcriptomics analysis, and genetic modification to enable isolation, purification and full characterization of previously unknown bacterial metabolites relevant to dental caries versus oral health. The project will be conducted by Oregon Health & Science University and is expected to be completed by July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $597.8k | 8/19/25 |