Project Grant R41DE034604
- This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
- This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a randomized clinical study led by Dr. Subramanian at Rutgers, The State University of New Jersey. The $168,228 award aims to evaluate the efficacy of a novel local anesthetic injection technique, the Temporo-Masseteric Nerve Block (TMNB), in reducing post-surgical pain and improving mouth opening for patients...
- This federal Project Grant award of $248,999.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research aimed at elucidating the underlying mechanisms of motor cortex stimulation (MCS) as a non-opioid alternative for chronic pain management. The primary objectives are to: 1) characterize the efficacy and neurobiological mechanisms of somatotopically-matched MCS in a rodent model of trigeminal...
- This $3,892,145 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), is funding research under the NIH Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of succinate signaling for pain relief in oral cancer. The primary objective is to determine if inhibiting the succinate receptor SUCNR1 can alleviate oral cancer pain by reducing inflammation and nociception (pain...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research by Function Therapeutics Inc. to investigate the use of a new class of small molecule compounds called Parmodulins for the treatment of neuropathic pain. The $499,863 award, granted on September 11, 2025, will fund research to synthesize and test various Parmodulins for their ability to modulate the...
- This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
- This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
- This federal Project Grant award for $1,587,553.00 was provided by the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant is focused on developing novel 5-HT3 receptor antagonists for the treatment of neuropathic pain. The key objectives are to: 1) use computational drug design approaches to identify novel 5-HT3 receptor antagonist chemotypes with potential for central nervous system (CNS) penetration and...
- This federal Project Grant award in the amount of $299,782.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The funding supports the development and validation of an MRI-compatible jaw metabolic stressor task to determine the jaw muscle metabolic stress and brain functional characteristics related to jaw pain perception during function. This research aims to create new models for studying...
This federal Project Grant award of $413,298.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support the development of a novel transmucosal local anesthetic cocktail (T-LAC) formulated into adhesive wafers for the treatment of subacute intraoral pain (IOP). The project, conducted by Trekka Therapeutics, LLC, in partnership with researchers at the University of Minnesota, aims to establish the feasibility of the T-LAC wafers in two key areas: (1) demonstrating the in vitro efficacy of CAPRO-based T-LAC formulations, including evaluating mucoadhesive strength, dissolution rate, and drug penetration; and (2) showing the in vivo efficacy and biocompatibility of the T-LAC wafers in a mouse model of dental pulp injury, with comparisons to existing treatments. This project seeks to address the critical need for long-acting, opioid-free relief of subacute dental pain, which is a significant public health issue.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $413.3k | 9/4/25 |